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Between 1989 and 2002, 222 patients were treated with 4-day continuous infusions of fluorouracil (1,000 mg/m2/d) and cisplatin (20 mg/m2/d) during weeks 1 and 4 of either once daily or twice daily radiation therapy. As a result, there are phenotypical populations of extensive and poor metabolizers.

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Most of the proposed solutions seem to us however not biologically plausible. Twenty-four hours later they were tested in a shuttlebox escape task.

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Finally, a conceptual framework for indicators of psychosocial impacts on children is presented. Cancer of the esophagus poses a unique challenge for students of cancer prevention. Unlike most compartmental models, PBTK models are developed to describe the effects of metabolism in the tissue where it occurs. This paper proposes a visual representation named scene tunnel for capturing urban scenes along routes and visualizing them on the Internet. Predicting aberrant behaviors in opioid-treated patients: preliminary validation of the Opioid Risk Tool.

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Fifty-six patients had preoperative, 1-year postoperative, and 2-year postoperative data. Induction of innate immune response genes by Sin Nombre hantavirus does not require viral replication. Involvement of nucleotides in glial growth following scratch injury in avian retinal cell monolayer cultures. Ultrastructure of stroma of marrow-enriched membranes with trilineal hematopoiesis.

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Nucleus of the solitary tract lesions augmented the FN pressor response and tachycardia. This study highlights the need for remote area health centres to be well resourced to meet these needs. Our findings also point to the necessity of immunochemical screening for expression of laminin alpha2 chain in atypical dystrophic adults as well as children. Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease.

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We herein describe 2 cases of emphysematous pyelonephritis, which can be added to the 42 cases previously reported. Evaluation of vaginal microflora in chronic inflammation of the adnexa The in vivo rate of hydroxyproline production was significantly greater than the in vitro rate in lung tissue from similarly treated mice.

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A new sensitive method developed to determine specifically inorganic mercury in the presence of organic mercury was used. In keratinocytes either null for alpha-catenin or blocked in VASP/Mena function, filopodia embed, but actin reorganization/polymerization is prevented, and membranes cannot seal. Counterparts of the retrograde response are found in the roundworm, the fruit fly, the mouse, and even in human cells in tissue culture. FR 139317 seems to be a selective ETA-receptor antagonist which competitively antagonizes the endothelin-1- and endothelin-2-induced contractions of guinea-pig isolated pulmonary arteries. These findings implicate this mechanism of CaN activation in a chronic neurodegenerative disease.

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These environments exist in tumors because their abnormal vascular networks result in an unstable oxygen delivery. On testing with highly diluted pilocarpine solution, a denervation hypersensitivity reaction of the sphincter pupillae was seen.

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After the right frontotemporal craniotomy, intracerebral hematoma was removed and coil packing of the affected cavernous sinus was successfully performed via the dilated superficial middle cerebral vein. Data were collected from a sample of 48 young individuals by clinical and radiological examination, saliva sampling and a dietary questionnaire. Thus, our findings suggest that targeting CXCR4 could provide some therapeutic interest for HER2 BC patients, whereas it has no impact or could even be detrimental for TN BC patients. Social dysfunctioning in these patients was rather limited, but was more pronounced in patients with a psychological disorder than in those without. Thiamine biosensor based on oxidative trapping of enzyme-substrate intermediate.

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PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcoma cells using OSU-03012 compound. The most reliable diagnostic technique, as used in our patient and supported by our literature review, is endoscopic retrograde cholangiopancreatography.

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Using specific phospho-serine antibodies, we identified phosphorylation of baculovirally expressed p53 protein at five distinct sites. According to their reactivity to BrT nuclear extracts and mammary carcinoma cell line MCF-7, seven hybridomas were selected and cloned. The individual and combined influences of three industrial solvents (namely xylene, toluene, and methanol) on certain parameters of liver function in laboratory rats have been studied.

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Our findings demonstrate lower prevalence of transplant-unrelated diabetes among ADPKD patients. We report the characterization of a molecule recognized on chicken T cells by the murine A19 monoclonal antibody that was generated by immunization with intestinal intraepithelial lymphocytes.

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A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo. We conclude that the ternary complex of HNF3 alpha, NF1/CTF, and the eH site forms a novel, composite regulatory element that is sensitive to the local DNA sequence environment and suggest that the transcriptional stimulatory activity of NF1/CTF depends on its higher-order interactions with other proteins during hepatocyte differentiation. Postoperative enophthalmos can be prevented by inserting bone grafts into orbital osteotomy gaps, correcting orbital volume/morphology following floor or wall outfracture/fragmentation, and preserving the periorbital supporting system. In Gram-negative bacteria, a dedicated machinery consisting of LolABCDE components targets lipoproteins to the outer membrane. Also featured are interviews with Monte Westerfield, PhD, Director of the Zebrafish Information Network (ZFIN) online database, and Principal Investigator of the Human Protein Reference Database (HPRD) project, Akhilesh Pandey, MD, PhD.

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The two AWC neurons are structurally and functionally similar, but the G-protein-coupled receptor STR-2 is randomly expressed in either the left or the right AWC neuron, never in both. The paroxysmal nocturnal haemoglobinuria stem cell may arise at any time during the evolution from aplasia through recovery and may disappear during full recovery of the bone marrow. Case history of an African woman presenting with advanced HIV and a painful conjunctival lesion is presented.

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Our results suggest that transplantation of NSCs intrastriatum may have therapeutic potential for TS. Finally, pharmacological inhibition of ERM phosphorylation with NSC663894 decreased mineralisation induced by phosphate and exogenous S1P.

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In a group of patients suffering from common variable immunodeficiency (CVID), levels of interleukin-6 (IL6) were measured and found to be in the normal range or even increased, for single patients. In this prospective, longitudinal, observational cohort study, we demonstrated that diabetic CAN was an independent prognostic factor for the future development of CKD in type 2 diabetes.

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Detection of herb-symptom associations from traditional chinese medicine clinical data. We found that fluorescence-labeled phospholipid analogs preferentially stain the mycolate layer. In this study, to clarify the physiological functions of these three LPXRFamide peptides (gfLPXRFa-1, -2, and -3), we analysed the localisation and hypophysiotrophic activity of these peptides using sockeye salmon, Oncorhynchus nerka, in which immunoassay systems for several anterior pituitary hormones have been developed. Evaluation of the long-term effects of synovectomy in rheumatoid arthritis We recorded event-related potentials to somatosensory and auditory stimuli in a passive change detection paradigm from 81 older and 38 young women and investigated their associations with cognitive performance.

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Our derivation of the DIB also suggests a method for continuously interpolating between the soft clustering of the IB and the hard clustering of the DIB. To investigate baseline factors associated with caregiver-reported wandering among community-dwelling veterans with mild dementia. Etched porcelain placement technique is simplified and easier than before. Neuronal loss and axonal degeneration are important pathological features of many neurodegenerative diseases.

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In the current study we focus on the involvement of dopamine D(2) receptors in the ventral hippocampus in memory performance and acetylcholine release. The Physical Function Scale was correlated with the ODI, Health Utilities Index, Centres for Epidemiologic Studies Depression Scale, Medical Outcomes Survey Social Support Scale, and an additional item from the Oxford Claudication Score.

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These findings suggest that DS placement is as effective as GJJ for the treatment of GOO in patients with unresectable pancreatic cancer, even in those with a long life expectancy. The molecular mechanisms, functional consequences, and human relevance of P450 downregulation by PAHs are poorly understood. Cockroaches are of vital importance medically and hygienically as they can disperse human pathogenic agents and are especially responsible for food contamination and spreading of food borne pathogens. Familial, interpersonal, and intrapersonal correlates of drug use: a longitudinal comparison of adolescents in treatment, drug-using adolescents not in treatment, and non-drug-using adolescents.

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Vaccination platforms must expand to include older ages including the second year of life. The distribution of the asymmetry index values along the isofrequency planes revealed systematic changes in the symmetry of the response areas. The glucose transporter GluT4 and secretory carrier membrane proteins (SCAMPs) colocalize in rat adipocytes and partially segregate during insulin stimulation. Hsp70 binding protein 1 (HspBP1) modulates the activity of Hsp70 but its biological significance has remained unclear.

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Expansion of the current class of bisphosphonates may lead to compounds that more selectively and potently target these cancers through inhibition of the mevalonate pathway. While investigating the mechanism of synergistic cytotoxicity between tamoxifen (TAM) and cisplatin (DDP) we developed a TAM-resistant variant of the human melanoma cell line T-289.

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To examine retinal function after the long-term, gene therapy-delivered expression of exogenous glial cell line-derived neurotrophic factor (GDNF). Purified normal rhesus monkey T cells were incubated with unconjugated FN18 or conjugated FN18-CRM9 and examined for differences in antibody binding, tyrosine phosphorylation, and CD3 internalization. The investigation is an attempt to explore the cause that generates high pressure in the distal oesophagus compared to that in the proximal part. The validity of enzyme localization is thus assured by the insolubility of the primary reaction product and does not depend on the rate of the second reaction step. A total of 600 participants (160 men and 440 women) who had received their HIV results after Voluntary Counselling and Testing for HIV at the Zimbabwe AIDS Prevention and Support Organization (ZAPSO) Mabvuku/Tafara Voluntary Counselling and Testing Centre were interviewed.

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Photodetection and Photoswitch Based On Polarized Optical Response of Macroscopically Aligned Carbon Nanotubes. All subjects underwent laboratory analyses and complete two-dimensional echocardiographic and 3DE examinations. The time evolution of electron populations and the electron covariance matrix is obtained as approximate solutions of a master equation.

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Determination of the elastic properties of graphene by indentation and the validity of classical models of indentation. Hydrostatic pressure changes in endolymph as well as perilymph and cerebrospinal fluid (CSF) following intravenous injection of glycerol, urea, and mannitol were studied in the guinea pig using a servo-controlled micropipet system.

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The Childhood Obesity Research Demonstration (CORD) project links public health and primary care interventions in three projects described in detail in accompanying articles in this issue of Childhood Obesity. Long-term effect of neonatal endotracheal intubation on palatal form and symmetry in 8-11-year-old children.

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The mass was hypointense on T1- and T2-weighted images and demonstrated ring enhancement after contrast medium injection. To evaluate retention protocols and use of vacuum-formed retainers (VFRs) among specialist orthodontists. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. Human antibody single domains are a promising new class of antibody fragments. The results of the present study are discussed with respect to possible functional interpretations.

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Problems of internal quality control (IQC): Analytical precision of clinical laboratory test has remarkably improved recent years because of the advancement of technologies including analytical procedures and instruments. To assess the association between AAM and CVD risk factors in a large population. The high prevalence of VTE in this patient population, its clinically silent nature, and associated morbidity and mortality indicate that prophylactic therapy is appropriate in those determined to be at increased risk.

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Acute effects of oral pirbuterol on myocardial oxygen metabolism and systemic hemodynamics in chronic congestive heart failure. C3H/HeN were shown to be high responder mice, whereas other H-2k strains, BALB.K, CBA/N, and B10.BR, were low responders. Preliminary investigations focussed on understanding the ionization process of SESI. In addition, the waste solvent generated was minimized by using SFE. Tactile stimulation improves neuroanatomical pathology but not behavior in rats prenatally exposed to valproic acid.

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Early studies in which the electrophoretic profiles of fluid from different regions of the epididymis were compared with other body fluids, such as blood serum, suggested that many proteins present in epididymal fluid were not found in other secretions and thus might be tissue specific. Here, we provide a morphometric analysis of more than 1,200 grape accessions. Directed connectivity of brain default networks in resting state using GCA and motif. In this review a survey of the interface of photochemistry, medicine and targeted drug delivery is given, especially focusing on phototriggered targeting in nanomedicine.

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We found that the gas molecules are entropically driven from open metal sites to larger neighboring spaces during the gas infusion period, matching the localized-to-mobile mechanism. Time flies: investigating the connection between intrinsic motivation and the experience of time.