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Topigen (Topiramate)
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Topiramate

Topigen is a prescription drug. It comes in four forms: immediate-release tablets, immediate-release sprinkle capsules, extended-release capsules, and extended-release sprinkle capsules. All forms are taken by mouth. Topigen oral tablet is available as the brand-name drug Topigen. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug. This drug may be taken in combination with other drugs to treat epilepsy.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Physical exercise in secondary prevention of coronary heart disease Using position-specific iterative BLAST, we have identified distant relatives of the PAPP-A N-terminal sequence stretch of 250 residues. The results suggest that the greatest concern among obstetricians who perform cesarean deliveries was malpractice litigation. Furthermore, by integrating multiple structures on the same membrane, complex sequential procedures are possible using a limited number of control steps.

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Spiral computed tomography is a new noninvasive diagnostic test for pulmonary embolism. The CCPN data model defines a storage model for NMR data, which greatly facilitates the transfer of data between different NMR software packages.

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We call on the concerned stakeholders to support the establishment of a systematic approach for use of SSC mechanisms in the health sector of Africa, designation of an African Centre of Excellence for SSC in public health and development of a regional mechanism for monitoring and evaluation of SSC initiatives in Africa. A notable example is the induction of angiogenesis, which occurs through the secretion of pro-angiogenic factors by both tumor and tumor-associated cells. The possible use of this form of therapy to treat pancreatic cancer is discussed. The role of cell density and pH on calcium influx was studied in normal and endotoxin-challenged cultured 3T6 fibroblasts.

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Apart from SAR97276, which also has a novel chemical scaffold that has had its development stopped, all other compounds in the pipeline belong to already known substance classes, which have been chemically modified. Academic metrics of 315 vascular surgery, 1,132 general surgery, and 2,403 other surgical specialties faculty were examined using institutional Web sites, Scopus, and NIH Research Portfolio Online Reporting Tools from September 1, 2014, to January 31, 2015. They did not consult because of psychoses or affective disorders, but mainly because of reactive conditions related to the stress of migration. We describe an approach to developing efficient and ethical biobank governance that includes all major stakeholders.

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Combinatorial methods have also been developed for the rapid analysis of binding energetics across protein interfaces. Cystatins in parasitic nematodes not only have the unique inhibition activity on cysteine proteases but also modulate the host immune response and have an important role in the immune evasion from host response and the adaptation to parasitism.

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The retention data demonstrated that the mechanism of protein retention in ion-exchange chromatography (IEC) involves interactions between the protein solute, the mobile phase constituents and the stationary phase. The authors report a 56 year old female patient with chronic hepatitis and both HCV-RNA positivity and a high titer of LKM-1 antibody on blood samples.

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Pathologic study revealed a pT1bN1M0 (stage IIb) tumor, with lymphatic involvement detected in a right recurrent nerve node. The results showed obvious up-regulation of microglial markers such as OX-18, OX-42 and OX-6 up to 21 days after formalin injection. Surgical exploration is primarily for the control of haemorrhage (which may necessitate nephrectomy) and renal salvage.

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We find no need to follow the practice of tricuspid valve excision for tricuspid endocarditis in addicts. Although most small water-soluble solutes and middle molecules can be satisfactorily removed by either conventional or newly developed dialysis strategies, targeting uremic toxins with cardiorenal toxicity at predialysis stage of chronic kidney disease may retard or prevent incident dialysis as well as the initiation/progression of cardiorenal syndrome.

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Food and Drug Administration approved lumacaftor/ivacaftor for use in patients with cystic fibrosis (CF). This was a cross-sectional, multicenter, observational study conducted in patients treated for hypertension in out-patient private clinics in Egypt, during October 2011 to June 2012. The number of gavage-related deaths or animals requiring euthanasia due to gavage problems was dramatically reduced, but the occurrence of incomplete vehicle retention during gavage was increased appreciably in halothane-anesthetized animals.

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These results indicate that miRNA-140 acts as a liver tumor suppressor, and that impairment of miRNA-140 function due to a deficiency of DDX20, a miRNA machinery component, could lead to hepatocarcinogenesis. This method may add to the current techniques available for detection of impending failure.

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Cryostat sections were cut and processed for the histochemical detection of the NADPH-diaphorase (ND)-activity. Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens. Thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is a type of extranodal lymphoma with a favorable prognosis. The phase composition, morphological properties, and the dissolution in SBF were characterized by using XRD, FTIR, EDS, SEM, and spectrophotometry. To compare the expression pattern of these cysts with non-tumorous odontogenic developmental cyst, dentigerous cyst was included.

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However, little is known about the precise mechanism that accounts for termination of toxin action. Heterologous expression of mating-type genes in filamentous fungi. Principles of the diagnosis and medical prevention of lead poisoning Functional studies of differentially expressed miRNAs were performed to investigate cell proliferation, migration, and invasion in OSCC cells.

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The trends reflected in the EEG parameters correspond to a gradual increase in fatigue levels of subjects with increase in cognitive loading. (1)O(2) generation from photoirradiation of a model photosensitizer Rose Bengal (RB), in initially air-statured phosphate buffered saline (PBS) was indirectly monitored with SOSG. Most of the remaining subunits seem to be of eukaryotic origin, recruited from pre-existing nuclear genes.

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Risk factors for preterm birth in Korea: a multicenter prospective study. The International Aortic Arch Surgery Study Group has been formed by 41 arch surgeons from 10 countries to better evaluate patient outcomes after aortic arch surgery. The WHO update eliminates the ambiguity in APA diagnosis in favor of criteria that emphasize clinical behavior (invasion, recurrence, and resistance to treatment) and molecular markers.

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These or other, unknown, nephrotropic HPyVs may potentially be shed in urine. The potential for MR-guided radiation therapy to improve outcomes and the challenges in its adoption are discussed. An evaluation was made of the effectiveness of an urban community health volunteer programme in Pokhara, Nepal, in sensitizing and motivating people for the improvement of health knowledge and skills and the use of services.

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ELECTRO-SURGERY WITH SPECIAL REFERENCE TO GOITRE AND MALIGNANCY. Clinical investigation of the positioning accuracy of acute pulpitis pain

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These results indicate that MetAP2 is a main regulator of proliferative and apoptotic pathways in mesothelioma cells and suggest that MetAP2 inhibition may represent a potential target for therapeutic intervention in human mesothelioma. In the remaining 520 cases, arthrography revealed extrameniscal pathology, sometimes associated with meniscal lesions, as well as other pathologies which were either negative or equivocal.

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Our results provide a better understanding of the tripartite pumps at the molecular level. The aquaporin NOD26 may provide a channel for ammonia, but the genes encoding the other transporters have not been identified. Circulating endothelial progenitor cells and especially endothelial colony-forming cells (ECFCs) are promising candidate cells for endothelial regenerative medicine of ischemic diseases, but the conditions for an optimal collection from adult blood must be improved.

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Characteristics of the reconstituted activity suggest that the same enzyme is responsible for ATP formation in untreated membranes. To investigate the presence of vanilloid receptor 1 (TRPV1) in human dental pulp and to correlate any expression with caries and pain. Some academic health centers have developed and implemented patient-centered clinical service standards for diverse areas of practice, however, the standards used appear to vary for some aspects of care, but not for others.

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Hence, the results are relevant for many practical applications. To assess whether direct measurement of ureteral length correlates with patient height or the ureteral length measured on intravenous urography in order to determine the appropriate ureteral stent length to be used for ureteroscopic surgery. Adaptive responses of peripheral lateral line nerve fibres to sinusoidal wave stimuli.

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pylori-host interactions will not only improve targeted diagnostic and therapeutic modalities, but may also provide insights into other diseases that arise within the context of chronic pathogen infection. Blood tests and prognosis in bladder carcinomas treated with definitive radiotherapy.

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Rat spleen and thymus tissues were fixed by immersion in fixatives containing different concentrations of paraformaldehyde, washed in sucrose phosphate buffer, dehydrated in acetone, infiltrated in a glycol methacrylate mixture in which the commonly used softener 2-butoxyethanol was replaced by butaandiol monoacrylate, and embedded. Alkaline phosphatase (AP) activity and expression of bone Gla protein (BGP), c-fos, and c-jun were compared in two transplantable osteosarcomas with high potentials for metastasis to the lung.

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In a double-blind study beclomethasone dipropionate inhaled as a dry powder in doses of 100 microgram four times daily and 150 microgram four times daily was compared with the conventional aerosol dose of 100 microgram four times daily in 20 outpatients with chronic asthma. Our finding, that transforming growth factor-alpha, but not transforming growth factor-beta or interleukin 1-beta mimics these EGF effects, indicates that progestin-enhanced TF expression in cultured HESCs requires activation of the EGF receptor (EGFR). Upon interaction with liposomes, detergents, and lipoteichoic acid, CP10A was shown by circular dichroism spectroscopy to undergo a change in secondary structure.

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Guidelines for the development of local standards of oral health care for people with dementia. The fluorescence anisotropy of both ANM alpha and ANM beta increased linearly with the addition of nonfluorescent beta or alpha subunit, and saturated at a protein ratio about 1, indicating that 1 mol alpha subunit binds to 1 mol beta subunit with high affinity in vitro. The results are discussed as reset of oscillations in human thalamocortical networks.

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Twenty-eight families were allocated randomly to either receive a 10-week dog based PA intervention or to a control group. Voluntary entropion, which has been reported only once before, was photographically documented in a 12-year-old girl. We therefore investigated the novel combination of bortezomib (Velcade), cladribine, and rituximab (VCR) in front-line and R/R settings in MCL and iNHL (NCT00980395). Pertussis toxin did not affect circadian cycling of the liver, suggesting that G(i/o) plays a specialized role in maintaining SCN rhythmicity.

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In conjunction with our epileptologist, we consider responsive neurostimulation for patients who have clinical features of temporal lobe epilepsy without clear localization on imaging and stereo-EEG. Ultrasensitive mechanical detection of magnetic moment using a commercial disk drive write head. The purpose of this study is to evaluate the postretention stability of the dental arches in Class II division 1 patients treated with four bicuspid extractions and the edgewise technique. Surgical therapy, which remains the treatment of choice for this curable entity, confirms the diagnosis. This architecture enables electron-selective mobility measurements in single components as well as bulk-heterojunction films as demonstrated in the prototypical polymer/fullerene blends.

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In problem herds more attention should be paid to rearing methods and selection of (A.I.) bulls. We demonstrate that Quark achieves state-of-the-art compression rates, and that, typically, only a small fraction of the reference sequence must be encoded along with the reads to allow reference-free decompression. Consecutive patients below 16.0 years treated for upper or lower UTI from 1 January 2009 to 31 December 2009 at Hvidovre Hospital in accordance with the guidelines of the department and the DPS. Analysis of the resulting phenotype is sometimes difficult, however, because individual genes have more than one function, and observed effects on complex behaviors are often a result of abnormalities of any of a number of individual processes. This phaeoid fungus has been rarely described as an opportunistic infection in immunosuppressed patients.

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In this contribution, we study the ephaptic stimulation between myelinated axons and show its relation with the separation between fibers and the conductivity of the medium that surrounds them. Furthermore, RR-variation correlates to known physiologic function.

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Direct ink writing of silica-bonded calcite scaffolds from preceramic polymers and fillers. In a randomized 4-phase crossover study, 12 healthy volunteers received 800 mg telithromycin, 10 mg montelukast, both telithromycin and montelukast, or placebo once daily for 3 days. CT-guided intensity-modulated radiotherapy for bladder cancer: isocentre shifts, margins and their impact on target dose.

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Carbon metabolism in developing soybean root nodules: the role of carbonic anhydrase. Rottlerin, a widely used PKC-delta-specific inhibitor, efficiently blocks these PV-induced tyrosine phosphorylation events. We compared results obtained from the groups that received selective IAF (a microcatheter inserted in intracranial arteries) and nonselective IAF (a microcatheter inserted in the cervical arteries). The intrauterine position of the fetus molds the femur by rotating it laterally and molds the tibia by rotating it medially. Possible downstream gene of GSK-3 signaling pathway, protein kinase C (PKC) was knocked down by siRNA in DRG explant.

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We used 0.20- and 0.45-microns-pore-size syringe-tip filters to recover spirochetes from cultures contaminated with other bacteria. Our results showed: (1) Cramps can be induced even after peripheral nerve block by electrical stimulation distal to the block. (254 nm) damaged non-dividing human skin fibroblasts: a major biological role for DNA polymerase alpha. Use of carefully selected donors with a history of past and current cocaine use does not result in worse outcomes. This paper describes efforts of the structural genomics project in the nuclear magnetic resonance (NMR) laboratory at the University of Science and Technology of China.

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The influence of the bending of sequences by the d(GpG)cisPt adduct binding of ER to estrogen response element (ERE)-like sequences was examined. Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency. Marrow stromal cell layers from 3 of 9 patients with this disorder failed to maintain granulocyte-macrophage colony-forming cells in vitro.

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Release of an insulin-like peptide from perfused extirpated cat legs in response to electrical stimulation of the sciatic and brachial nerves and to administration of ACh, bombesin, oxytocin and glibenclamide. Corelease of the two transmitters at Lugaro cell synapses is suggested by the fact that both GABA(A) and glycine receptors open during individual L-IPSCs. RCN Deputy President Professor June Clark has been elected unopposed as President of the Royal College of Nursing. Subcellular characterization of the primordial germ cell antigen PG2 in adult oocytes.

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We also provide evidence that knockdown of Nore1B also impairs polarized redistribution of Ras at the B cell-T cell immune interface. This study aimed to identify the factors associated with blood components requirements. As a genetically distinct pathogen, CA-MRSA is generally susceptible to multiple non-beta-lactam antimicrobials.

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Finally, I discuss the distribution of reproductive patterns across both, molecular and morphological phylogenetic trees in Phoronida proving that parental care has evolved independently several times in this phylum. Linezolid induced black hairy tongue is a rare benign reversible side effect of linezolid therapy. Radiographic skyline views of the patellofemoral joint were taken at baseline to measure the femoral sulcus angle. Consequently, this may result in outliers (i.e., very low values) in that group. We present a new approach that uses a mixture of several distributions to model the set of P-values or of test statistics.

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Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. In the studies presently reviewed, a decrease in weight by 1 kg resulted in a reduction in blood pressure by 3.4/1.3 mm Hg in hypertensive patients and in normotensive subjects the corresponding reductions averaged 1.4 mm Hg and 0.6 mm Hg for systolic and diastolic pressure, respectively.

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In addition, intracerebroventricular (ICV) administration of insulin to mice activated mTORC1 pathway in the hypothalamic arcuate nucleus, a key site of central action of insulin. A system approach to intravenous thrombolysis in acute myocardial infarction in community hospitals: the influence of paramedics. This study compares different lower-limb length measurements using tests of lower-limb upright full-length radiography and anteroposterior radiography of load-bearing hips. MTs labeled with 20-bp or 50-bp dsDNA molecules showed significantly different trajectories according to the DNA length, which were in good agreement with values predicted from electrophoretic mobilities measured for their minus ends.

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Occupational kofron unida diarrhea for a week mortality from cutaneous malignant melanoma was evaluated for deaths occurring in British Columbia from 1950-1978 by using age standardised proportional mortality ratios (PMR). Phase-matched waveguide four-wave mixing scaled to higher peak powers with large-core-area hollow photonic-crystal fibers. It is an everyday phenomenon of personal and cultural life, as the Chaudhary et al. An extensive guide on how to enter experimental data into is available from the XMetDB wiki.

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Reconstructing penile supersonic transporter (SST) deformity using glanulopexy (glans fixation). It remains controversial whether a survival benefit is achieved once metastases have occurred. clomipramine citrate of magnesia Molecular dynamics simulation of quasi-two-dimensional water clusters on ice nucleation protein. Budesonide by inhalation and placebo were tested in 18 patients with moderate chronic bronchial asthma.

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Sonography of brain abscesses complicating norfloxacin tablet use in the classroom Citrobacter neonatal meningitis. Future enquiry to assess the efficacy of future and current teaching practices is needed to facilitate continued improvement. This review addresses health issues, exposure assessment and an international review of compensation criteria, trends and prevention efforts.