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We found that the induction of XBP1 mRNA and pXBP1(S) was greatly reduced in M19 cells as compared with wild-type cells, leading to a marked reduction in the extent of induction of XBP1-target gene. The DAP flap is a good addition to the armamentarium of reconstructive surgeons when a relatively thin fasciocutaneous flap with minimal hair is desired. This analysis provides critical information for preoperative patient counseling.

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Access to Patient Centered Medical Home (PCMH) care has not been explored among older racial/ethnic minorities. The number of yearly operations in a clinic did not correlate to long-term survival in this study. The inverse of the response time when the field was switched on in both POLY and MONO was proportional to E2, which is the same field dependence as the response time of LMWLCs.

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A total of 3,841 differentially expressed genes (DEGs) were obtained, some of which were associated with homologous chromosome behavior and cell cycle control during meiosis. Boundary zone infarcts were associated with internal carotid artery disease and limitation of anterior or posterior circle of Willis anastomoses.

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Immunohistochemical localization of androgen receptors in female mole rat (Spalax leucodon) tissues. Unity and variety of ethical principles: human dignity endangered. Additionally estrogens are a recognized mitogenic factor for the epithelium of the mammary gland, acting proliferative on the glandular tissue and in the same way influence on the increased risk of breast cancer development. In view, recent rise in human Dirofilaria repens infections in several regions of the world, is considered as emerging zoonotic infection transmitted to man by zooanthrophilic blood sucking insects. The efficiency of humectants as skin moisturizers in the presence of oil.

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Identification of Clostridium difficile as the major pathogen has led to a rational successful approach to therapy and has widened the spectrum of associated disease. The relative efficacies of the nine agonists were inversely correlated with the size of the amino or ammonium group. To establish a new, objective, statistically based severity score for familial Mediterranean fever (FMF).

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A modified technique of septal extension using a septal cartilage graft for short-nose rhinoplasty in Asians. When expressed in SF9 and COS-1 cells, FLRT1 and FLRT2 migrate as 90- and 85-kDa proteins, respectively, and both are glycosylated. Photochemotherapy in vitro--direct effect on epidermal lectin-binding of psoriatic and normal skin In the absence of limit values for carcinogenic substances in the air, the health impact assessment can be based on quantitative risk assessment. Low 25D status increased the risk for all endpoints, but a lengthy follow-up diminished these risks towards the null.

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Finding the best outcome measures for research and quality assurance purposes in terms of validity, sensitivity to change, length and ease of completion is crucial. E-cadherin was further associated with abdominal pain severity in the IBS group overall, but unrelated to IBS subtype.

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There is no consensus on the definition of successful HCT preparation, with few tools to assess transition readiness and/or self-management. One prominent feature of lipid-induced glomerular injury in animal models is the accumulation of mesangial matrix. Proliferative disorders of the skin respond to many agents that suppress polyamine metabolism.

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These data highlight the complexity of the relationship between abuse history and pain and illustrate the need for further investigation of potential pain-related correlates of abuse. However, serum ECP concentrations and peripheral blood eosinophil counts were not different among the patients with mild, moderate, or severe asthma. Classical acupuncture in the treatment of rhinitis vasomotorica and rhinitis pollinosa The expression of 16/38 TNBC-specific genes was associated with alteration in DNA methylation.

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Gamma interferon induced surface expression of interleukin 2 (IL-2) receptors on normal human monocytes and the monocytoid cell lines U937 and HL60. Similarly, 2-O-alpha-D-glucosaminyl- (5) and -galactosaminyl-1-phosphatidyl-D-chiro-inositol (6), which differ from the corresponding pseudodisaccharide motif of the GPI anchors only in the axial orientation of the phosphatidyl moiety, were also synthesized and asymmetrically inserted into LUVs. This data may be useful to provide improved insight into the histopathology of this organ involvement.

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Classification and epidemiology of R plasmids of Enterobacteriaceae Clearance of cationized LDL cholesterol from a muscle depot is not enhanced in human apolipoprotein A-IV transgenic mice. Successes of Soviet functional surgery of laryngeal cancer and the prospects for its development Plasmid-injected corneas remained clear and free of inflammation.

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Thoughts and Response to Authority-Perpetrated, Discriminatory, and Race-Based Violence. Remarkably, a host of biochemical, enzymatic, and cellular alterations that are operative in accelerated arterial aging have also been implicated in the pathogenesis and progression of arterial diseases. The objectives of the study were to test the hypothesis that shorter-sleeping children would show higher nighttime energy intake and to examine whether the additional calories were from drinks, snacks or meals. Nucleic acid hybridization for detection of cell culture-amplified adenovirus.

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Group sessions may improve social interactions and additionally increase the quality of life. The paper presents studies on nutritional foramina of the mandible.

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Two peptide-PNAs targeted to the essential gene inhA were growth inhibitory and caused cell morphology changes that resemble that of InhA-depleted cells. The role of the autonomic nervous system in modulation of baroreflexes was investigated by pretreatment of the animals with propranolol or atropine.

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To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable triple Ser to Ala mutant (Op18-AAA), and to mimic phosphorylation, a triple Ser to Glu mutant (Op18-EEE) to egg extracts and monitored spindle assembly. This link provides an important clue for the understanding of the mechanisms of thrombocytopenia associated with Ad5. The dexamethasone suppression test and pituitary-adrenocortical function. To explore the molecular mechanism of fibroblast growth factor 8b (FGF8b) in promoting epithelial-mesenchymal transition in prostate cancer DU145 cells.

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These results suggest that the signature motif is essential to the phosphomonoesterase activity of lipoprotein e (P4). The effects of trimegestone (1 mg/kg/day orally), a novel norpregnane progestin, and 17 beta-estradiol (10 micrograms/kg/day subcutaneously), alone and in combination, on bone mass and turnover were investigated using an experimental model of osteoporosis involving ovariectomized rats. We propose that this mechanical effect could even trigger a ferroelectric to paraelectric transition in chiral phases. A few patients have gender reassignment outside of the newborn period.

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On the basis of these findings, the authors conclude that panic disorder in the community is similar among African-Americans and whites with respect to lifetime prevalence, age at onset, years of disorder, symptom distribution, suicide attempts, and comorbidity with other psychiatric disorders. No changes in intensity or relaxation times were noted before or after Gd-DTPA administration in two animals with 2 hours of occlusion. Secosiolariciresinol diglucoside accumulates (up to 28.65mg/g dry matter) in the later developmental stages in both forms, mainly ester-bound in the lignan macromolecule and slightly in a free form.

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Neutral endopeptidase 24.11 (NEP) is a cell-surface peptidase that cleaves and inactivates the neuropeptides endothelin-1 (ET-1) and bombesin, which are implicated in progression to androgen-independent prostate cancer (PC). Phosphorylation of Mms21 occurred in unchallenged cells, but was more abundant in the presence of DNA damaging agents. Stereoselective degradation kinetics of tebuconazole in rabbits.

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While gene knock down can be induced by RNA interference in many insects, methods to misexpress genes are much less developed. However, potential risk to groundwater is relatively unknown because few studies have investigated the probability of frac hits on abandoned wells. In two studies comparing intravenous quinine with intravenous artesunate, intravenous artesunate was more efficacious and safe for use in pregnant women. In periodic catatonia, the lack of brothers and sisters and in particular a lack of elder sisters proved to be an essential factor. Several potential functional polymorphisms in the DNA base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been reported.

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An Interim Analysis of an Advance Care Planning Intervention in the Nursing Home Setting. The aim of this study was to investigate mucin expression in hypertrophic adenoids. Ion Binding to Transport Proteins using Isothermal Titration Calorimetry. Not only have the earliest stages--adhesion and epithelial penetration--never been seen in the human, but also the trophoblastic plate and lacunar stages that follow are not available for modern investigative methods.

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Cancer research is a national and international priority, with the efficiency and effectiveness of current anti-tumor therapies being one of the major challenges with which physicians are faced. In order to avoid other antibiotics which interfere with plasma and CSF level determination of a given antibiotic the authors use a chemical method of established specificity. Effect of prolonged cimetidine therapy on gastric acid secretion in man.

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We calibrate the accuracy of Methyl-Spec-seq using a novel two-color competitive fluorescence anisotropy method that can accurately determine the relative affinities of two sequences in solution. In one case the JC antibody titre was significantly higher in the CSF than the serum and we suggest that this finding is diagnostically useful.

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Moreover, long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus, two hallmarks of memory function, are both decreased by SAR127303. Vaginal specimens were obtained from 66 women with normal pregnancy and 30 women with preterm labor with intact membranes. Children born preterm performed less accurately and/or less rapidly on all tasks.

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After adjustment for demographic differences, recruitment patterns explained over 90 percent of the spatial variation in abundance of a common damselfish among seven coral reefs. Induction of mitochondrial xanthine oxidase activity during apoptosis in the rat mammary gland. MRI revealed contrast enhancement of the cisternal and cavernous portions of the third cranial nerve and high signal on a FLAIR sequence within the ipsilateral medulla at the presumed location of the trigeminal nucleus and tract. One or two trials with a given flesh (lamb or rabbit) specifically suppresses the attack upon the averted prey but leaves the coyote free to attack the alternative prey. The authors have determined that the ligaments are stronger in the cervical region and that they decrease in strength as the spinal cord descends.

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These results indicate a new role for alpha-catenin in local regulation of actin assembly and organization at sites of cadherin-mediated cell-cell adhesion. Increasing evidence has suggested that microRNA (miRNA) dysregulation may contribute to tumor progression and metastasis.

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The presence of components related to the main intrinsic polypeptide (MIP) of chick lens membrane. The observed maturational decline in the LPH activity is very similar to adult-type hypolactasia observed in humans. This study tries to show, by means of biomechanic work, the efficiency of reinforced plate in anterior column in a segmental pelvic loss, illustrated with a clinical case, which shows the socket stability of hip prosthesis.

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Restoration of elbow flexion is the main objective in the treatment of brachial plexus palsies affecting the upper roots. Its association with renal diseases though not very common but have been described in many studies. Ideally, the clinical approach to fetal seizures should involve a multidisciplinary team spanning the pre- and postnatal course to expedite early diagnosis and optimize management, as illustrated by this patient.

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The subjects from Tohoku Study of Child Development, which was designed to examine the developmental effects of prenatal exposures to such hazardous chemicals, were 489 mother-newborn pairs with complete data including smoking habit during pregnancy. epidermidis was identified as the causative organism of UTIs in children with underlying urinary tract abnormalities. We reviewed 82 patients between 2009 and 2016, 12 of which were diagnosed as DNM by clinical and computed tomography findings. Remarkably, the distribution is identical in the shear layer and the core.

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Since autoantibodies directed against unknown antigens are present in the sera of these patients, sera samples were examined for the presence of autoantibodies directed against the Fas molecule. The study of frailty may provide an explanation for the downward spiral of many elderly patients after an acute illness and hospitalization.

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Modification of erucic acid content in Indian mustard (Brassica juncea) by up-regulation and down-regulation of the Brassica juncea FAT TY ACID ELONGATION1 (BjFAE1) gene. Key features of the syntheses of the pentasubstituted 4-pyridone were a regioselective bromination of a 4-pyridone derived from kojic acid, a subsequent Cu-mediated introduction of the thioether, and a directed lithiation/iodination step. In addition, illness relapse can occur if psychotropic medications are discontinued. Exocytosis of Chlamydia is into the tubal lumen and not into the subepithelial spaces.

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Detecting semen antisperm antibodies in the clinical laboratory. There is a conflicting evidence on safety and efficacy of transcatheter aortic valve implantation in patients with preoperative chronic kidney disease (CKD).

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Expectorated sputum samples were probably the major limiting factor in low positivity for detection of P. Data collected during the period from November 1980 to September 1984 have been plotted on graphs. Angiopoietin-like protein 2 (ANGPTL2) plays an important role in inflammatory carcinogenesis and tumor metastasis.

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It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nanoparticles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability. While invasion of U-NB1 cells was inhibited by blocking antibodies against CD57, neither invasion of SK-N-BE(2)-C cells nor adhesion of U-NB1 and SK-N-BE(2)-C cells was attenuated.

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Upper cervical cord compression as cause of death in osteogenesis imperfecta type II. Increased sialidase activity in serum of cancer patients: Identification of sialidase and inhibitor activities in human serum.

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MK2206, an allosteric Akt inhibitor, has been shown to reduce cellular proliferation in other cancers. The psychological and cosmetic aspects of breast conserving therapy compared with radical mastectomy. Attitude and past vaccination uptake explained a considerable amount of variance in the intention of HCWs to receive the influenza vaccine. Psychosocial occupational therapy intervention with AIDS patients.

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Following our previous publication we have received critical comments to our conclusions as well as new data that are strengthening our findings. We present the characteristics and prognosis of an unselected population of AHF patients. A Physiological Approach to Prolonged Recovery From Sport-Related Concussion. Defining neurodegeneration on Guam by targeted genomic sequencing.

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Identification of novel WFS1 mutations in Italian children with Wolfram syndrome. MS was able to systematically rank both strength and milkiness, although less consistently than controls, and for tea strength his rankings were in the opposite order. We have developed both a merging algorithm and a scoring system for molecular interactions based on the proteomics standard initiative-molecular interaction standards. Secondary cytoreduction for ovarian cancer following cisplatin therapy. BioStudies presents a solution to ensuring that all these data and the associated publication(s) can be found coherently in the longer term.

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The cerebellar-vestibular basis of learning disabilities in children, adolescents and adults: hypothesis and study. Graphical and logistical regression analysis was used to determine variables independently predictive of adjacent infection. Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. The effects of carbamazepine (CBZ) on spontaneous secretion of prolactin (PRL) and after stimulation with thyrotropin releasing hormone (TRH) were evaluated. We performed a 2-year prospective study in a general medical and surgical ICU including, exceptionally, paediatric cases.