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Vessel rings were suspended in organ chambers and their isometric tension was recorded. We exposed rats to a cafeteria-style diet for eight weeks starting at age 21 or 70 days. Novel compound heterozygous mutation of the MC2R gene in a patient with familial glucocorticoid deficiency. This first-in-human trial of a mitochondria-targeting drug in iPAH demonstrates that PDK is a druggable target and offers hemodynamic improvement in genetically susceptible patients, paving the way for novel precision medicine approaches in this disease.

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The spleen plays a central role in host defense against malaria in animals. The effects of phonological awareness and rapid automatized naming were mediated by the other variables in the model. Participants had a range of unmet health information needs that extended beyond family planning and fertility. These findings suggest that AVPD and SP may be alternative conceptualizations of the same disorder. The incidence of drug-induced anaphylaxis deaths appears to be increasing and our understanding of the multiple and complex reasons for the unpredictable nature of anaphylaxis to drugs is also expanding.

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To determine the magnetic resonance (MR) imaging characteristics of endometrial polyps and the accuracy of MR imaging in distinguishing endometrial polyps from endometrial carcinomas in a case-control study. The effects of reactive oxygen species (ROS) on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in solid cancers have yet to be clearly defined. A high-affinity site for acetylcholine occurs close to the alpha-gamma subunit interface of Torpedo nicotinic acetylcholine receptor.

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The cell cycle regulation of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH)/uracil DNA glycosylase (UDG) gene was examined in normal human cells. Recombinant DNA methods greatly extend (even outside the plant kingdom) the sources from which genetic information can be obtained for crop improvement. Aberrant BCL10 expression can occur in other types of ocular adnexal lymphomas besides MALT lymphoma. Treatment of active duodenal ulcer with oral cimetidine: a multicenter controlled endoscopic trial. The pH corresponding to the phase transitions and the characteristics of the aggregates were determined by means of a combination of physical techniques: static and dynamic light scattering (SLS and DLS), fluorescence spectroscopy, cryo-TEM and diffusion- and (31)P NMR.

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Blood samples, nasal- and conjunctival swabs were obtained at the same time and used for the detection of the equid gammaherpesviruses EHV-2 and EHV-5 using consensus herpesvirus PCR and type-specific qPCRs. To our knowledge, this is the first reported case of calciphylaxis recurrence after subtotal parathyroidectomy. Greenfield vena caval filter for management of selected cases of venous thromboembolic disease following hip surgery.

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We will recruit 208 participants aged 35-74 years who have intermediate cardiovascular risk. Bacteria of the family Enterobacteriaceae were isolated from the tissues of a number of wild and cultivated plants.

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Designing effective nutrition support regimens for critically ill patients requires an understanding of the energy needs of each patient. Specific therapy in severe fetal intrauterine growth retardation: failure of prostacyclin. The TGF-beta1 rise may be associated with hepatocyte injury and systemic response to massive burn. Our Bayesian approach scores Medline abstracts for probability of discussing the topic of interest according to the frequencies of discriminating words found in the abstract. The basis of the method is the detection of radioactive lead-210, which decays with a 22-year half-life when it is unsupported by its long-lived precursor, radium-226.

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In study B, myxothiazol and oligomycin, inhibitors of mitochondrial respiration, were added to investigate the site of action of NO. Cocultivation of naive SMNC with phagocytic cell-free SMNC (M phi-MNC) from infected mice resulted in the inhibition of lymphocytic blast transformation stimulated with various lectins.

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If choice of therapeutic techniques was a contributing factor to increased lengths of stay, however, this would have major cost/effectiveness implications for program planning. TSC may be a better option due the lack of association with long-term antimicrobial resistance. That cutpoint was then validated in a set of 345 tumors by univariate and multivariate analyses.

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POEMS syndrome is a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia. Local ancestry may contribute to the disproportionate burden of subclinical and clinical cardiovascular disease among admixed African Americans compared with other populations, suggesting a rationale for admixture mapping.

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The association of taurine, aspartate, and glutamate in plasma cannot be simply transferred to the neutrophils intracellular level. Does lactobacillus vaccine for trichomoniasis, Solco Trichovac, induce antibody reactive with Trichomonas vaginalis? Familial carriers were detected by polymerase chain reaction-single strand conformational polymorphism analysis, restriction enzyme digestion and direct sequencing of PCR products. The design of EPIC can serve as a template for studies investigating the relationship between process and event rates across health-care institutions. Health-related quality of life in patients with bronchiolitis obliterans.

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The blood pressure and heart rate were stable during operations. The incidence in patients with a family history of cancer was 1.29 times greater than that in patients without such a family history, and the incidence in patients with a family history of breast cancer was about three times greater than that in those without it (p less than 0.01).

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In conclusion, these results show a differential hormonal regulation of GH and PRL receptor gene expression in the pancreatic islets, which may play a role in the adaptive beta-cell growth during pregnancy. Recently, weekly autologous serum injections have been shown to induce a prolonged remission in this disease.

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We now show that in syd-1 and syd-2 mutants, synaptic vesicles and numerous other presynaptic proteins fail to accumulate at presynaptic sites. Ultimately, therapy should be based on a shared decision making process. A case of congenital sucrase-isomaltase deficiency in man was investigated.

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Results suggested that with the increasing length of alkyl chain, the antiaggregation efficiency of lipopeptide inhibitors towards hIAPP11-20 increased gradually. The anticancer effects of levamisole, tegafur and their combination were experimentally compared in rats on the 1, 2-dimethylhydrazine (DMH)-induced colonic cancers. We therefore evaluated the frequency of use and acceptability of the Revised Geneva Score (RGS) and the Pulmonary Embolism Severity Index (PESI), and explored which factors were associated with rule use. Conventional neuroimaging examinations are typically normal in concussed young athletes.

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At the cooperative group level, efforts to breach this clinical impasse have focused on incorporation of antiangiogenesis therapy, medical optimization, and identification of less toxic regimens. Health care professionals and policy makers often only had a limited if any training in searching for relevant and objective information efficiently. The light-inducible system successfully activated the artificial miRNA and, consequently, regulation of its target gene under blue light.

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To induce murine cutaneous sclerosis, mice were subcutaneously injected with bleomycin, while untreated control groups were injected with phosphate-buffered saline. Fifty children (100 ears) on the waiting list for bilateral myringotomies and ventilation tube insertion for recurrent acute otitis media or otitis media with effusion. Potentiation of cortical excitability consisted of an increased firing in response to intracellular stimulation and a reduction in threshold current for spike initiation.

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Epithelioid hemangioma of bone: a potentially metastasizing tumor? While the placenta undoubtedly makes an important contribution to plasma cytokine levels, production by maternal peripheral blood mononuclear cells (PBMCs) and other tissues is also likely to be significant, although to what extent remains undetermined. When the infant was 13 months of age, successful surgical repair was undertaken by performing an intraatrial transposition of venous return using the Senning procedure and by closing the ventricular septal defect with a patch.

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To demonstrate its practical application, biosynthesis pathways for the production of important products, e.g. We highlight neural manipulation techniques that currently allow for causal testing of these hypotheses. In Africa, the consumption of raw milk and raw meat, and the development of bushmeat consumption as a cheap source of proteins, represent one of the principal routes for human contaminations with BTB. Delayed repolarisation of the myocardium already occurs in a substantial fraction of patients with cirrhosis with only a mild increase in portal pressure.

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Bariatric Surgery Registries: Can They Contribute to Improved Outcomes? The Carotid Sinus as an Etiological Factor in Sudden Anaesthetic Death. These cases indicate that quinidine can indeed cause an SLE-like syndrome. In this context, an aggregation of cases by a two-stage approach (stage 1: excision, stage 2: reconstruction) is particularly important. On the cause of the variation in tissue-maximum ratio values with source-to-detector distance.

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Ex vivo effects of ibogaine on the activity of antioxidative enzymes in human erythrocytes. This topology was not purely local but regulated by fluxes and flows over the whole AR.

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Pharmacotherapy and gene transfer strategies to raise the relative level of structural proteins may minimize the problems faced by astronauts in readapting to Earth-gravity. The work presented herein is aimed at determining the response functions of the bacterium by applying a stepwise chemoattractant stimulus while it is swimming forward or backward. Mean radiation risks for genetic anomalies and carcinogenesis following VCUG during childhood were estimated to be up to 15 per million and 125 per million, respectively.

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Male Sprague-Dawley rats were fed on either a purified, fibre-free diet or a diet in which half the maize starch was replaced with uncooked amylomaize or potato starch (equivalent to 100 or 200 g amylase-resistant starch (ARS)/kg diet respectively). Patients with upper and lower motor neuron spinal cord injuries were observed to determine whether cystography immediately before excretory urography induced iatrogenic dilatation of the upper urinary tract that was indistinguishable from true pathological dilatation. Solar Radiation: An Anomalous Decrease of Direct Solar Radiation. Micelle size was dependent on temperature and the nature of the aqueous medium. Effects of acute bleeding on oxygen supply to the skeletal muscle in dogs.

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3D map distribution of metallic nanoparticles in whole cells using MeV ion microscopy. Objective evaluation of contradictions between clinical and anatomopathological diagnoses We investigated how the inability of mutant pneumococci to produce pneumolysin altered the pattern of inflammation and cellular infiltration into the lungs. During that period, blood flow continued, but at a less than normal rate.

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The patient was treated by one-stage excision with reduction mammaplasty. All nodules kept pure ground glass appearances before surgical resection and their last time of thin-section CT imaging data before operation were collected. This Perspective article discusses questions that are related to standard operating procedures, computational resource management, and data storage and integration in the context of recent developments in the sequencing and bioinformatics service markets. Clinical assessments and the substance abuse literature tend to focus on drug-specific individual SUDs rather than considering the more complex multiple SUDs, which can be more challenging to treat.

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The first dose followed transfusion of the eighth red blood cell (RBC) unit, with additional doses 1 and 3 hours later. If the stress condition is overwhelmed, then UPR signaling shifts to apoptotic pathways. Compared with their hearing age-mates, children with CIs performed marginally more poorly on fast mapping as measured by the comprehension probe and more poorly on retention as measured by comprehension and production probes. Endocan is markedly overexpressed in severe erectile dysfunction. Mutations that cause decreased catalase activity may contribute to susceptibility to inherited type 2 diabetes mellitus.

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These results support the hypothesis that birds influence the evolution of Batesian mimicry in P. Cyclodipeptides: An Overview of Their Biosynthesis and Biological Activity.

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We therefore propose circadian behavioural variation as an independent axis of the fish personality, and the study of chronotypes and their consequences as a novel dimension in understanding within-species fish behavioural diversity. Drainage with suction and the instillation of steroid around the prostheses seemed to be effective in reducing the incidence of capsular contracture. The results suggest that p34 is a synaptic vesicle specific protein with a widespread distribution in the nervous system.

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Stem cells: units of development, units of regeneration, and units in evolution. The exact biological details still remain to be defined and seem beyond the capabilities of current technologies, but perhaps, this will serve as a springboard for further theoretical inquiry into in vivo approaches. Electrophysiological evidence suggests that when an auditory event is predicted, processing is sped up, i.e., the N1 component of the ERP occurs earlier (N1 facilitation). Thus while proficient lymphocytes always produced proficient cell lines, deficient lymphocytes, in 3/8 cases, gave rise to more proficient cell lines. Corneal epithelial basement membrane is a highly specific extracellular matrix which is made up of lamina lucida and lamina densa.

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It co-related with the high grade testicular damages, as a poor predictor of spermatogenesis. The recipients were transplanted and either not treated or treated with FTY720 by gavage for 21 days to evaluate the allograft survival.

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Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases and phosphorylated carbohydrates. Expression of all three of the molecules was additionally increased by stimulating the cultures with heat-killed Listeria monocytogenes.

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The status of women in medicine at the Brown University School of Medicine. It is important that dentists have a good understanding of these conditions so that the risk of potential complications of dental treatment in affected patients is reduced as much as possible. Immunohistochemical localization of laminin was performed on whole mounts of developing epithelia after growing neurites were localized with a histochemical stain for esterase. The plunge is inserted through the myocardium into the ventricular cavity perpendicular to the epicardium.

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Many radiographic indices that are used to assess adolescents for femoroacetabular impingement rely on an ossified posterior acetabular wall. Indirect evidence suggests that particular fragments may have been selected to confer different properties on the domain and that rearrangements are frequently selected for their effect on DNA structure. Cost-effectiveness of routine viral load monitoring in low- and middle-income countries: a systematic review. The use of proton-carbon heteronuclear multiple bond correlation (1H-13C HMBC) gradient NMR spectroscopy leads to the complete assignment of the correlations of the spins of H2a and H3a with the ester and carboxyl carbons of rosmarinic and caffeic acid, even at room temperature, and confirms the results of the above methodology Quantitative results are in reasonable agreement with reverse phase HPLC measurements. Endocytic activity and ultrastructural cytochemistry of lysosome-related organelles in epiphyseal chondrocytes.

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Sera were obtained from 16 patients presenting with acute myocardial infarction (MI) before treatment with streptokinase and 1 and 6 months post treatment, and from 100 controls. CSEA is an efficient and suitable anesthesia technique in LA for ASA physical status classification grade I healthy patients. Responses of nontransformed, preneoplastic and tumorigenic cells to ultraviolet irradiation. Definition of the requirements for clinical long-term studies (patient number, length). Concentrations of the metals studied in tissues of grey mullet and gei wai shrimp were found to be safe for human consumption.

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Results of measurements demonstrating the potentials of these spectroscopic methods are presented. Other nonspecific biochemical markers of bone metabolism, such as urinary hydroxyproline and urinary calcium, were also present in significantly greater amounts in active acromegalic patients. One of the most stringent tests for chemical accuracy of a hybrid quantum mechanical/molecular mechanical (QM/MM) molecular dynamics simulation method would be to directly compare the calculated vibrational spectra with the corresponding experimental results. One disadvantage was the repeated use of the same cohort of students. Between January 1974 and June 1986, 26 patients with 42 femoral false aneurysms were treated at the Princess Alexandra Hospital.

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Developmental regulation of the lung in preparation for life after birth: hormonal and nutritional manipulation of local glucocorticoid action and uncoupling protein-2. Influence of epidermal growth factor on growth of bovine mammary tissue in athymic nude mice. There was radiographic evidence of new bone fill of prior radiolucent defect in all patients. Identification of high-risk behaviors among victimized adolescents and implications for empirically supported psychosocial treatment. We investigated the fluctuation dissipation theorem for this constant drag motion by comparing it with the motion of Brownian beads that were incorporated into the cells by an electroporation method.

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Self reported smoking cessation verified by plasma or salivary cotinine concentration. Accumulation of appreciable amounts of free 24(S),25-epoxycholesterol was associated with lowered levels of reductase. Global and regional central TT can be assessed in the first pass perfusion imaging.