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Dicorate (Divalproex)

Dicorate is a stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Dicorate dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Dicorate may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Check for active clinical trials using this agent.

Other names for this medication:
Divalproex, Depakote, Dicorate, Divaa, Desval,

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Cloning and assessment of mycobacterial promoters by using a plasmid shuttle vector. Mud protein is also normally found in association with other structures during egg development: at the spindle poles of meiosis I, at the spindle poles of early cleavage and syncytial embryos, in the rosettes formed from the unfertilized products of meiosis, with the fusomes and spectrosomes that anchor the spindles of dividing cystoblasts, and at the nuclear rim of the developing oocyte. The transcription of Escherichia coli lactose operon was induced and the conditions for 32P maximal incorporation into mRNA which is synthesized on this operon were made. The HNMECs were obtained from the inferior turbinate and subsequently cultured. The application of mifepristone to emergency, luteal phase and menstrual induction contraception is being assessed in clinical research programs conducted in accordance with international standards for good clinical research.

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Wound-healing and benzodiazepines: does sleep play a role in this relationship? This study utilized a method of presenting electrical and acoustic stimuli that were continuously alternating across ears. To characterize movement of fluorescein and its glucuronide across the blood-retinal barrier. Determination of glucosamine in horse plasma by liquid chromatography tandem mass spectrometry.

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Social stress and recovery: implications for body weight and body composition. We found that octylcaffeate, a semisynthetic caffeic acid derivative, strongly inhibited the growth of human histiolytic lymphoma U937 cells in a dose- and time-dependent manner via apoptosis.

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Colorectal cancer and adjacent normal specimens from 186 patients who had not received neoadjuvant chemotherapy were collected. However, the functional consequences of this selection have yet to be validated. We found a blunted sympathetic and accentuated parasympathetic response to postural change in subjects with depressive disorder, suggesting that the autonomic impairment and early ANS dysfunction may exist among depressed individuals.

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