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Dicorate (Divalproex)
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Divalproex

Dicorate is a stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Dicorate dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Dicorate may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Check for active clinical trials using this agent.

Other names for this medication:
Divalproex, Depakote, Dicorate, Divaa, Desval,

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Wound-healing and benzodiazepines: does sleep play a role in this relationship? This study utilized a method of presenting electrical and acoustic stimuli that were continuously alternating across ears. To characterize movement of fluorescein and its glucuronide across the blood-retinal barrier. Determination of glucosamine in horse plasma by liquid chromatography tandem mass spectrometry.

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Social stress and recovery: implications for body weight and body composition. We found that octylcaffeate, a semisynthetic caffeic acid derivative, strongly inhibited the growth of human histiolytic lymphoma U937 cells in a dose- and time-dependent manner via apoptosis.

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We have found that type I GAP, type II GAP, and type I NF1 show markedly different biological activities in vivo. Histologic sections of the palatal biopsy that had been previously diagnosed as squamous cell carcinoma were reviewed, and a final diagnosis of carcinosarcoma was established. Sodium taurocholate injection into the pancreatico-biliary duct also caused the bacterial growth in the pancreas.

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Most previous studies on the controls of thirst and salt appetite in rats have focused on systemic factors. In the utriculus, striolar hair cells were selectively damaged while extrastriolar hair cells were relatively unaffected.

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The Canoe protein is necessary in adherens junctions for development of ommatidial architecture in the Drosophila compound eye. The authors stress the diagnostic importance of a purposeful X-ray investigation of craniovertebral area in cases of neurologic symptoms and external signs of dysplasy, and the value of timely diagnosis for prevention of neurologic complications.

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The prognostic value of non-inducibility after ablation and of a change in inducibility status have not been investigated in large studies. Aspirin therapy is recommended commonly for symptomatic extracranial carotid artery occlusive disease.

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Colorectal cancer and adjacent normal specimens from 186 patients who had not received neoadjuvant chemotherapy were collected. However, the functional consequences of this selection have yet to be validated. We found a blunted sympathetic and accentuated parasympathetic response to postural change in subjects with depressive disorder, suggesting that the autonomic impairment and early ANS dysfunction may exist among depressed individuals.

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Circulating adiponectin levels are significantly up-regulated in vivo upon activation of PPARgamma. Fractures in pediatrics show epidemiological characteristics which are different from fractures in adults. Acr-dG is mutagenic and potentially carcinogenic and may represent a useful biomarker for the early detection of cancers related to smoking or other oxidative conditions, such as chronic inflammation.

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Pulmonary function in normal subjects and patients with sarcoidosis after bronchoalveolar lavage. Carbon monoxide and cardiovascular disease: an analysis of the weight of evidence. We suggest that an insufficient suppression of the contralateral medial temporal function is partly responsible for nonlateralizing IAP memory tests.

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A multiyear, multicenter survey of medical student career choice was conducted with all five UAE medical schools. The results indicate that the indoor-produced compounds in the new homes will be more influenced by the aging decreases of emission source strengths than ventilation systems. Analysis of this novel pathway of PtdIns(3,4,5)P(3) synthesis in cellular membranes leads us to conclude that in vivo, Type Ialpha PIPkinase also acts as a PtdIns(3,4)P(2) 5-kinase. Evaluation of rapid, simple species classification for group D streptococci and clinical significance of the isolates A correlation between preoperative facial nerve weakness and the quality of nerve graft function was not found.

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