Dicorate is a stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Dicorate dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Dicorate may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Check for active clinical trials using this agent.
Other names for this medication:
Divalproex,
Depakote,
Dicorate,
Divaa,
Desval,
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