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Cationic trypanocides may act as antagonists of polyamine function. The frequency of occurrence of the disease in domestic animals is unknown. Gas chromatographic measurement of plasma levels of sodium valproate: tentative therapeutic range of a new anticonvulsant in the treatment of refractory epileptics.

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Several families of regulatory genes have been implicated in anteroposterior patterning of gastrulation-stage vertebrate embryos. Cine computed tomography is a relatively new cardiac imaging mode with very high time and spatial resolution that has the potential to accurately diagnose constrictive pericarditis. This study shows that chronic aspirin use is associated with lower mortality rate within 30 days after hospital admission in a large cohort of patients with pneumonia. Sacral neuromodulation is now a minimally invasive treatment as a result of improvements in surgical technique, and it has good long-term results. The clinical pattern of this disease has some resemblance with polymyositis.

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Ex vivo gene delivery of an Abeta-degrading protease reduces amyloid plaque burden in transgenic mice expressing human APP. One Thousand Spinal Anaesthesias: With Special Reference to Complications and Mortality. In particular we study the passive force in a protein as a function of the extension of the protein. Using dual wavelength time-lapse fluorescence microscopy, we analyzed the morphogenesis of three synaptic components: dendritic spines, postsynaptic densities (PSDs), and presynaptic vesicles. However, I am not certain that learning from management theory or modifying medical education will be powerful enough to change the system.

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Perioperative management of diabetic patients involves optimizing glycemic control and negotiating comorbidities to help reduce complications and obtain results on par with nondiabetics. Quantitative mass spectrometry-based approaches in cardiovascular research. Furthermore, one of the two major low energy conformational families of anandamide also overlaps with the cannabinoid CB(1) receptor ligand HU210, which is in line with anandamide being a dual activator of TRPV(1) and the cannabinoid CB(1) receptor. Effect of levamisole on immunoglobulin secretion into lacrimal fluid in experimental herpetic keratitis TAF2 binds to multiple motifs within the TAF8 C-terminal region, and these interactions dictate TAF2 incorporation into a core-TFIID complex that exists in the nucleus.

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By contrast, the expression of cytochrome c, cleaved-caspase-3 and cleaved-poly ADP ribose polymerase was increased following HMGN5 knockdown. Substitution of the ring nitrogen markedly decreased or abolished inhibition, but loss of the C-6 hydroxy group, as in 6-deoxy-DIM and 6-deoxy-6-fluoro-DIM, enhanced inhibition, particularly of the lysosomal alpha-mannosidase. It was an endo-beta-1,4-xylanase showing optimum temperature 40 degrees C and optimum pH 6.0.

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The Purkinje cells of the vermis, in general, are generated later than those of the hemispheres, and with a reverse gradient from caudal to rostral: the Purkinje cells of the posterior vermis (lobules X-VI) being produced ahead of the Purkinje cells of the anterior posteriorly directed wedge of early-produced Purkinje cells through the vermis. This paper compares the performances of an electroencephalography (EEG)-based movement intention decoder in two groups of severely paralyzed chronic stroke patients: 14 with subcortical lesions and 14 with mixed (i.e., cortical and subcortical) lesions.

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For both EMC and BWT models, using an increasing number n of events for calibration leads to narrower confidence intervals for the design ratios. Circulating autoantibodies were characterized by immunoblotting and ELISA using a recombinant form of the immunodominant BP180 NC16 A domain. We describe a case of bilateral Bochdalek hernia diagnosed prenatally.

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This paper introduces a classification algorithm, which uses two frequency ranges, mu and beta rythms, for feature extraction using common spatial pattern (CSP) along with support vector machine (SVM) for classification. Sinus slowing and pacemaker shift caused by adenosine in rabbit SA node.

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IVB significantly reduced subfoveal CT, choroidal blood flow, and subretinal fluid absorption in eyes with chronic CSC. This technology routinely allows many hundreds of proteins to be detected over a mass range of approximately 2000-70 000 Da while maintaining the spatial localization of the proteins detected. To determine whether reproductive isolation in gynodioecious Silene nutans results from allopatric divergence or from ecological adaptation following secondary contact, we investigated the pattern of postzygotic reproductive isolation and hybridization in natural populations using two phylogeographic lineages, western (W1) and eastern (E1). The extent of the morphogenetic defect caused by the T206A mutation depended on hypha-induction conditions.

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For evaluation of the functional relevance of these SNPs with IL-17A and IL-17F production, the serum levels of IL-17A and IL-17F were investigated in 107 and 109 patients as well as 33 and 52 healthy individuals, respectively, by ELISA assays. The resulting C-terminal protein extensions show evidence of selection, contain functional subcellular localization signals, and their readthrough is regulated, arguing for their importance. In this work we describe the case report of a woman affected by cancer of the sigmoid colon and with a positive direct antiglobulin test (DAT) and indirect antiglobulin test (IAT). For alcoholic women, a longer duration of abstinence was associated with better performance on Affect Naming.

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We analysed time- and dose dependent modifications produced on plasma membrane molecular composition and on lipid microdomains expression (caveolae and lipid rafts) that represent specific signalling platforms. Secondary outcomes were the frequency of liver transplantation and otherwise cause-specific mortality.

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A review of 562 postoperative scanograms identified 102 patients (53 women) with a KA TKA in one limb, no other skeletal abnormalities in either limb, and symmetrical rotation between limbs on the scanogram. Joint Estimation of Relatedness Coefficients and Allele Frequencies from Ancient Samples. Ultrastructural markers of tubular transport within the rat nephron in experimental diabetes insipidus. Prenatal ultrasonic diagnosis of the extreme form of prune belly syndrome. Gap repair efficiently retrieves DNA fragments up to 133 kilobases long from P1 or BAC clones.

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Wide but not impermeable: Testing the riverine barrier hypothesis for an Amazonian plant species. Complementation studies on heterokaryons proved that the underlying genetic defect is non-allelic with that of patients with ataxia telangiectasia (complementation groups AB-E) and the Nijmegen breakage syndrome, but identical with the case described by Conley et al.

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Both models are verified retrospectively with survey data collected on a large scale in China over the past years. SCr and eGFR can be used as the diagnostic indices for early renal damage of SGA infants. The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats. It also fails to interfere with the inhibitory activity of nordihydroguaiaretic acid on lipoxygenase. The alternans resulted from the interplay of the recovery kinetics of the calcium and transient outward current inactivation gates.

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Although lateral gene transfer events likely account for these anomalies, with the data at hand we were not able to establish with confidence the bacterial donor lineage that gave rise to the respective Trimastix enzymes. Vasovagal syncope in humans and protective reactions in animals. Synthesis of pyrrole-imidazole polyamide oligomers based on a copper-catalyzed cross-coupling strategy. All-Union State Control Research Institute of Veterinary Preparations

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Oral administration of tripelennamine (histamine H1-receptor antagonist) and cimetidine (histamine H2-receptor antagonist) twice daily for four days had little or no effect on the lesion formation. A retrospective case series study was conducted on 41 patients with large KCOTs (the maximum diameter of the tumors exceeded 5 cm) treated at our institution between September 2003 and April 2011. Female rats were trained to detect a vertical, 60-Hz electric field using the same apparatus and procedure we used previously to study behavioral detection of the field by male rats. Trends in the maternal investment of harbour porpoises are uncoupled from the dynamics of their primary prey. They were designed to overcome erythromycin A resistance within Gram-positive cocci.

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Epithelioid sarcoma is a rare type of soft tissue sarcoma affecting the extremities, particularly the hands and fingers. The purpose of this study was to investigate cellular and behavioral effects of 5-HT1A receptor agonist 8-OH-DPAT in a rat model of levodopa-induced motor complications.

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We evaluated effectiveness and safety in the clinical setting, highlighting drug cost pressures, using our national Scottish PIBD biological registry. The most pronounced changes were observed at the 7th and 14th dps, and were followed by decrease toward control levels at the 30th dps. Increasing the delay between sepsis initiation and resuscitation increases disease severity, need for resuscitation, and sepsis-associated brain mitochondrial dysfunction.

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We investigate this patterning process analytically and obtain estimates for the pattern wavelength and speed of spread. Here, we describe a computational approach to predict temporal regulator activity levels from the gene expression of its transcriptional targets in a network motif with one regulator and many targets. Purification of genomic DNA is performed with phenol: chloroform: isoamyl alcohol extraction and ethanol precipitation. There were no consistent effects on bone mineral, after adjusting for age, of gravidity or parity, age at menarche, age at first delivery, use of oral contraceptives or estrogen replacement therapy, various sex hormones, nor any of the other reproductive factors assessed.

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In this context, diabetes may influence the bone in multiple pathways, some with contradictory effects. The antibody could recognize 6His-ATRX-C2193-2492 protein specifically. This highly supervised disposition is subject to control by the Biomedicine Agency, which is responsible for delivering and controlling authorisations for embryo research.

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Completeness, amendment rates, rate of timely ordering of ancillary studies (KRAS in T4/N1 colon carcinoma), and structured data file extraction were compared for four different synoptic report generating methods. An integral, outer-surface, 38,000-dalton fragment bears most of the band 3 carbohydrate. The course is presented in three modes: a lecture, a demonstration, and then a film.

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Different degrees of incompatibility manifested by different plasmids suggest a possible polygenic control of the incompatibility. Tracing the use of computers in the radiology department from administrative functions through image acquisition, storage, and reporting, to early attempts at improved diagnosis, we begin to imagine possible new frontiers for their use in exam interpretation. To compare random urine protein to creatinine ratio (p:c ratio) with 24-h urine protein excretion rate in pregnant women with a suspicion of pre-eclampsia. All necessary parameters for structure elucidation such as multiplet structure, coupling constants and integration values can be detected unambiguously.

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Effects of rejecting diffusion directions on tensor-derived parameters. Allogenic tendon with partial sheath grafting can be used as a new biological material for repairing the tendon and sheath defect. Perception of facial profiles: influence of female sex hormones and personality traits. Three months postoperatively bilateral hemimandibulectomies were performed. This expectation will be adjusted for general details particularly gender, age, marital status, domicile and type of primary caregiver.

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Primary cardiac sarcoma complicated with cerebral infarction and brain metastasis: A case report and literature review. This study investigated the role of the let-7 family and Dicer1 in the stemness of endometrial carcinoma cells.

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Patients with limited financial resources can expect similar outcomes as patients with commercial insurance. In conclusion, prolactin levels in rats following atypical antipsychotic treatment may not be fully predictive of the clinical situation. Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies. Excessive weight gain during pregnancy is a risk factor for postpartum weight retention and future weight gain and obesity. Overall, it appears that some resacas of the US-Mexico border region are contaminant sinks and could pose potential health or reproductive problems for fish and wildlife, and humans that consume fish from those sites.

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Angio-computed tomography and angiography did not reveal the location of the endoleak. Nudge, embarrassment, and restriction-replies to Voigt, Tieffenbach, and Saghai. The effect of airway closure and of its prevention by positive end-expiratory pressure. Little is known about changes of myocardial perfusion in patients undergoing coronary revascularization or medical therapy. This study was designed to investigate the ability of a chronic blockade of angiotensin II type 1 receptors with losartan to reverse the endothelial dysfunction present in N-nitro-L-arginine methyl ester (L-NAME)-treated hypertensive rats and the possible dependence of this effect on bradykinin B2-receptor activation.

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After TRT, mpMRI findings remained stable in patients without biopsy progression, whereas PI-RADSv2 score increase was identified in patients with Gleason score upgrade on follow-up biopsy. Outcome of using magnetic resonance imaging as an initial screen to exclude vestibular schwannoma in patients presenting with unilateral tinnitus. Micro-coil NMR to monitor optimization of the reconstitution conditions for the integral membrane protein OmpW in detergent micelles. The centrosome-nucleus complex and microtubule organization in the Drosophila oocyte.

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The reactivity of individual C--H bonds in the methyl(trifluoromethyl)dioxirane TFDO oxygenation of stereogenic methylene groups in conformationally homogeneous monosubstituted cyclohexanes (2) has been determined. Mitoxantrone and prednimustine combination chemotherapy in breast cancer. The presence of a characteristic radiographic finding, the ring sequestrum, is virtually diagnostic of this abnormality. 23-th Congress of Romanian Pneumology Society, 2014-- competition between generations

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the central maternity hospital and six community centres in the Slovenian capital city of Ljubljana. We did not find differences between high anger women and low anger women in mean levels of CRP, but we did find significant inverse relationships between CRP and some anger control characteristics. The diagnosis of branchial cyst was confirmed histologically in each. Immunocytochemical and morphometric study of prolactin cells during amphibian morphogenesis. Expression of wild-type MDM2, but not the mutant MDM2 defective either in Rb interaction or in RING finger domain, promotes cell cycle S phase entry independent of p53.

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The sensillum cone is comprised of an inner stem and a guard wall, neither of which is perforated. For model refinement, we modified our CASP11 molecular dynamics (MD) based protocol by using explicit solvents and tuning down restraint weights. Young male subjects, 8 with hypertension grade I, with BMI 25 kg/m(2) (HT), 10 with hypertension grade I, and BMI 30 kg/m(2) (HT OB), 14 healthy controls with BMI 30 kg/m(2) (OB), and 13 healthy controls with BMI 25 kg/m(2) (C) underwent the Stroop test. We enrolled 33 patients (4 male and 29 female subjects) with SH and CAD in this study.

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A 12-month follow-up of an influenza vaccination campaign based on voluntary adherence: report on upper-respiratory symptoms among volunteers and non-volunteers. Similar results were obtained using a quotient creatinine clearance/ammonia excretion, which enabled the differentiation of PN from the other groups. Quality of Life Following Repair of Large Hiatal Hernia is Improved but not Influenced by Use of Mesh: Results From a Randomized Controlled Trial. Researchers from different disciplines bring to a project their different perspectives of the research problem.

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The review process was facilitated through the peer review process of the Journal of Heart and Lung Transplantation and ultimately endorsed by the leadership of the ISHLT PH Council. The lymph node metastasis rate and ratio of AEG are high and influenced by many clinicopathological factors. Pharmacologic approaches to rhythm versus rate control in atrial fibrillation--where are we now? Participants completed a rhyme judgment task to word pairs presented unimodally (auditory- or visual-only) and cross-modally (auditory followed by visual).

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Peptide presentation was measured by a new, highly sensitive, ex vivo Ag presentation assay that was based on the testing of freshly isolated cells from infected spleens with peptide-specific CD8 T cell lines in an IFN-gamma-specific ELISPOT assay. These AVR form interstitial nodal spaces, with each space composed of a single CD, two AVR, and one or more ascending thin limbs or prebend segments, an architecture that may lead to solute compartmentation and fluid fluxes essential to the urine concentrating mechanism.

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Electrocardiographic left ventricular hypertrophy has low diagnostic accuracy in middle-aged subjects. Retention of African-American and White youth in a longitudinal substance use study. Warm, humid environments with high atmospheric vapor pressure contribute to population risk. To verify the efficacy of the flow channel, the effect of fluid shear stress on platelet adhesion to a fibrinogen-coated glass surface was tested.