Clariva is a semisynthetic macrolide antibiotic, structurally very similar to erythromycin. It inhibits protein synthesis by penetrating the cell wall and binding to the 50S ribosomal subunit. The absolute bioavailability of Clariva after oral administration is 50-55%, which probably underestimates its systemic activity, as it undergoes extensive first pass metabolism to its active metabolite, 14-hydroxyClariva. Limited data are available on the distribution of Clariva in humans. It appears to be distributed into most body tissues and fluids. However, no data is available on CSF penetration of Clariva. Elimination of Clariva follows nonlinear kinetics. It is extensively metabolized in the liver and excreted as parent drug and metabolites in urine, and faeces.
Other names for this medication:
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An evaluation of the CODABAR symbol in blood-banking automation. Effects of carvedilol and propranolol on circulatory regulation and oxygenation in cirrhosis: a randomised study. We conducted a literature review to evaluate the potential for the choice of economic evaluation approach to impact allegron patient information leaflet amoxicillin on the adoption decisions recommended by economic evaluation studies.