Letonal can be used in combination with other diuretics, primarily furosemide, to produce additional diuresis (generally a mild increase) or to decrease potassium excretion. In addition, as an aldosterone antagonist, Letonal is considered a neuroendocrine modulator (aldosterone receptor blocker). One human study reported that low-dose Letonal (subdi -uretic doses) reduced heart failure mortality by approximately 18–40% and this effect was attributable to its neuroendocrine modulatory effects. Letonal is also used in the management of fluid retention associated with noncardiac disease such as hepatic disease and nephrotic syndrome. Letonal might be particularly useful as a diuretic in the setting of right heart failure causing ascites.
Other names for this medication:
Spironolactone,
Aldactone,
Aldactazide,
Aldactazine,
Aldazida,
Aldazide,
Aldozone,
Alexan,
Alizar,
Carpiaton,
Espirone,
Espironolactona,
Expal,
Kespirona,
Lanx,
Letonal,
Osiren,
Osyrol,
Practon,
Prilactone,
Spiractin,
Spiresis,
Spirix,
Spiroctan,
Spirolang,
Spirolon,
Spiron,
Spirono,
Spironolacton,
Spironolactona,
Spironolakton,
Spironolattone,
Spirotone,
Verospiron,
Xenalon,
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Buspirona,
Victrelis,
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