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In a rat model of myocardial ischemia (1 h) and reperfusion (up to 24 h), there was a marked and significant activation of PARP in the ischemic borderzone, as determined by poly(ADP-ribose) (PAR) immunohistochemistry. Cdc25 (Cdc2 activator) and Wee1 (Cdc2 inhibtor) are important determinants of mitotic timing in all eukaryotes. Effect of instructions on the disappearance of steadily fixated luminous figures. In both non-treated and estrogen-treated rats the anterior deafferentation reduced the firing rates significantly (P less than 0.05 in the non-treated rats and P less than 0.01 in the estrogen-treated rats), while the posterior deafferentiation did not change the firing rates significantly.

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In vitro evaluation of the effects of gefitinib on the modulation of cytotoxic activity of selected anticancer agents in a panel of human ovarian cancer cell lines. Patient demographics, Numerical Rating Scale, and the Brief Pain Inventory were recorded.

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The yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription. Surgical management of pulmonary arteriovenous fistula in a female patient.

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Recognition of Treponema pallidum antigens by IgM and IgG antibodies in congenitally infected newborns and their mothers. Maze learning and motor activity deficits in adult mice induced by iron exposure during a critical postnatal period.

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Solidarity: an innovative perspective in the management and organization of Sanitary Surveillance actions. Application of Navigated Ultrasound for Assessment of the Anterior Pelvic Plane in Patients With Degenerative Hip Diseases. Interheme electron interaction effects do not play a significant role. An important feature of the T7 system in plants was the near-uniform expression in the independently transformed plants, in contrast with the large variations observed in transgene expression under the direct control of plant promoters.

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Pulsed magnetization transfer and continuous wave irradiation techniques are analyzed and compared for saturation efficiency and radio-frequency (RF) power requirements at 1.5 and 0.5 T. Spurious fractional charge on dissociated atoms: pervasive and resilient self-interaction error of common density functionals. Finally, integrin alpha1-null mice develop morphological changes of early tubular necrosis and increased apoptosis of renal medullary cells following dehydration. The correlation of miRNAs dysregulation and biology of ALL demonstrates that specific miRNA may be a potential therapy target. Our detection of a normal capacity of thalassaemic peripheral blood target cells to response to hGH and IGF-I suggests that these patients do not suffer from a specific defect in receptor and/or post-receptor mechanism(s) involving the response of these cells to both peptides.

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The Structure of Irish General Practice over 23 years was the third in a series of national studies that examined the development of general practice in 1982, 1992, and 2005. Epigenetic mechanisms of melatonin action in human SH-SY5Y neuroblastoma cells.

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Little is known about symptom characteristics of treated achalasia patients and their effect on health-related quality-of-life (HRQoL). The data from the present study show significantly higher CTGF staining in phenytoin-induced gingival overgrowth tissues compared to controls, cyclosporin A-, or nifedipine-induced gingival overgrowth.

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Five-year results from a phase 2 study of oral fingolimod in relapsing multiple sclerosis. The BCSCS is a simple and quick measurement for use in future studies Further studies are needed to determine whether this technique leads to less morbidity and improved clinical outcomes. JAGGED controls growth anisotropyand coordination between cell sizeand cell cycle during plant organogenesis.

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Evaluation of the severity of congenital aortic valve stenosis by M-mode echocardiography. Relapses continue during pregnancy and increase in frequency postpartum. A plunge electrode system (plunge) was developed that registers discrete deflections during VF. Incorporating long-term satellite-based aerosol optical depth, localized land use data, and meteorological variables to estimate ground-level PM2.5 concentrations in Taiwan from 2005 to 2015. Osteoporotic patients with vertebral fractures have a significantly impaired quality of life compared with osteoporotic patients without vertebral fractures.

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QT prolongation and ventricular tachycardia due to roxithromycin The DNA methyltransferase of the AluI restriction-modification system, from Arthrobacter luteus, converts cytosine to 5-methylcytosine in the sequence AGCT. Data from SDS/PAGE and Western blotting show that the cloned enzyme was identical to that of the wild-type strain. Bilateral traumatic abducens nerve palsy without skull fracture and with cervical spine fracture: case report and review of the literature. Schiff bases and N-alkylated/arylated derivatives of chitosan were characterized as adsorbents of lead ions and are studied at monomer level.

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A total of 11 622 subjects participated at age 16 years and 11 261 subjects participated at age 30 years. A review of the literature related to volunteers who work with these two populations was conducted. Fulminant meningococcemia is a rare clinical form of meningococcal disease which has been frequently fatal. This study was conducted to investigate the effect of Se supplementation on prostate cancer incidence in men at high risk for prostate cancer.

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The production of thromboxane was increased in SLE patients compared with controls, and this increase was highest (two-to threefold rise) when antiphospholipid antibodies were detectable. Although the mean serum concentrations of tyrosine and glutamine concentrations were lower in the dialysate, the serum and dialysate concentrations of other amino acids did not differ.

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This situation has a profound impact on the methods in diagnostic tumor pathology, since it requires precise pre-therapeutic tumor characterization to support the clinical management of the individual case. If nasal obstruction is present, intervention should be considered as part of the routine therapy for obstructive sleep apnea syndrome. Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats. DNA barcode variability and host plant usage of fruit flies (Diptera: Tephritidae) in Thailand.

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The eyeground findings deteriorated further with impairment of renal function. Interestingly, IKKepsilon still inhibits HCV expression in the presence of neutralizing antibodies to IFN receptors or in the presence of a dominant negative STAT1alpha mutant. To test our hypothesis that nicotine, a component of cigarette smoke, may exert an injurious effect on the fetal brain stem, we administered nicotine in drinking water to Sprague-Dawley rats prior to and throughout the first 20 days of gestation.

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The aim of the current study is to determine whether human bladders with an M2 contractile phenotype also have a greater density of bladder M2 receptors. This study provides the first evidence that LGI1 controls neuronal cell survival, suggesting its role in the development of the nervous system in relation to the pathogenesis of neuroblastoma and ADLTE. Therefore, laser therapy can be used as an alternative to or extension of existing treatment protocols.

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Evaluation of the effect of the femoral articular surface material on the wear of a metal-backed patellar component. Interestingly, the MDT-1 cell homogenate did not have a similar beneficial effect. Patient-specific contour-fitting sheet electrodes for electrocorticographic brain machine interfaces. These failures cannot be accounted for by f(-alpha) scaling models such as a linear superposition model or a model based on two-dimensional occlusions in the image plane. One hundred and seven public health facilities with tuberculosis (TB) service and 66 private pharmacies in 14 provinces.

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Natural killer cell activity in nasopharyngeal carcinoma before and after radiotherapy In this review, we will discuss the nature and sources of ROS, drug-based therapeutic strategies for scavenging ROS, and EPC based therapeutic strategies for treating oxidative stress-related CVDs.

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While SCD is publicly remarkable and like any death, tragic, the prevalence of SCD in young athletes is very low and the potential for false positive results is high. In reconstruction of cartilage defects, autogenous transplantation is known as a reliable and experienced method. Siderophore-drug conjugates have shown great potential in active drug delivery to target pathogenic microbes.

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The basal sialic acid secretion in renal patients did not differ from that of the controls, but in patients with peptic ulcers it was significantly higher. This antigen-dependent activation and killing required 24 hours of co-incubation of RPE with resting CD8 T cells specific for beta-gal. With exfoliatin 100 micrograms/ml, intraepidermal blisters were clearly visible, occurring either between the basal cells and the lowest intermediate layer or between the first two intermediate cell layers.

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Laparoscopic sleeve gastrectomy (LSG) at present one of the most commonly performed surgical treatments for morbid obesity worldwide. Combined kidney and pancreas transplantation is one valuable treatment of patients with type I diabetes who developed the long-term secondary complications of the diabetes, with pre-end or end-stage renal disease. We investigated how HPR1 is involved in RTE1ox ethylene insensitivity in Arabidopsis. Stem cell induction via granulocyte colony-stimulating factor (G-CSF) administration is utilized in the treatment of various diseases.

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Characteristic multifractal behavior for different molecular systems is obtained from the f(alpha) spectra. Effect of drying phase on the agglomerates prepared by spherical crystallization. We found that ADH3, the major mitochondrial alcohol dehydrogenase, is regulated in a manner similar to ADH1. The methods employ dry-chemistry reagents and the recently developed two-photon excitation (TPX) fluorescence detection technology. The LeuT-fold is a paradigm structure for APC superfamily amino acid transporters and carriers of sugars, neurotransmitters, electrolytes, osmolytes, vitamins, micronutrients, signalling molecules, and organic and fatty acids.

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I report here that SC35 was sufficient on its own to form a committed complex with human beta-globin pre-mRNA. Effect of leech on VSMCs in early atherosclerosis rats via p38MAPK signaling pathway We used the human PC-3 prostate cancer cells, analyzing cell growth with trypan blue exclusion, indices of the cell cycle with flow cytometry and apoptosis with flow cytometry and analysis of DNA fragmentation on simple agarose gel.

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Accordingly, this paper focuses on issues which would make economic appraisal more useful to policy-makers than it currently is. HL-60 and K562 did not express p53 m-RNA, while the other four cell lines all expressed high levels of mutant p53 protein. Chronic venous disease treated with sulodexide: a survey among primary care physicians in Mexico. The long-term effect of repeated intentional weight loss and weight regain on the risk of gallstone disease in men is not clear.

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The equivalence fails, however, when the phase-difference receptive field model is replaced by the position-shift model. The haplotype CTCC showed significant correlation with pulmonary TB. However, the lack of uniform criteria for the diagnosis of sleep-disordered breathing in children and variation in methods used to assess the outcome of surgical therapy limit our current knowledge and should be addressed by future research. By contrast flow-related dilation at 10 and 20 microliters/min was significantly diminished. Few cases of primary cardiac lymphoma (PCL) are found in the literature.

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The therapeutic drug monitoring begins to extend from specialized laboratories into the practitioners office. Factors affecting biodegradation of 2-chlorophenol by Alcaligenes sp. Anaplasma phagocytophilum outer membrane protein A interacts with sialylated glycoproteins to promote infection of mammalian host cells. A subsequent face-to-face meeting produced agreement on items not reaching consensus during the Delphi process. To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC).

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Do clinical and quality of life scores change over time after hip resurfacing? In the kidney, proximal tubular cells actively excrete organic anions of both endogenous and exogenous origin. Corrigendum: Regulation of T Cell Differentiation and Function by EZH2. These findings led us to propose for the first time a common behavior of OXA enzymes in CRAb. Liberal perioperative fluid administration is an independent risk factor for morbidity and is associated with longer hospital stay after rectal cancer surgery.

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Roles of moral philosophy in appropriated bioethics: a response to Baker and McCullough. Continuation or withdrawal of life-sustaining procedures in newborn infants: a study in 4 centers for neonatal intensive care

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However, the extensive application of cisplatin inevitably causes drug resistance, which is a major obstacle to cancer chemotherapy. It is suggested that DHK may be a valuable adjuvant therapy for DC. TRPV1 is expressed in a subpopulation of primary afferent neurons that express several different neurotransmitters. This amoeboid-like movement uses a parasite adhesin from the thrombospondin-related anonymous protein (TRAP) family and a set of proteins linking the extracellular adhesin, via an actin-myosin motor, to the inner membrane complex. These polysaccharides are fibrillar and determine to some degree the fungal shape.

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Sensitive luminescent reporter viruses reveal appreciable release of hepatitis C virus NS5A protein into the extracellular environment. In vitro adhesion and biofilm formation of 4 bacterial strains on 15 different commercial brackets, in standard culture mediums with and without addition of either serum or human saliva was evaluated by quantitative real time PCR after extraction of bacterial DNA. Infants move more, particularly around the second year of age, and move in a different way to adults. Unfortunately, a subset of patients have partial or no response. The full-length transmembrane alpha chain formed a complex with p88, whereas a soluble variant consisting of most of the luminal portion of the alpha chain exhibited only minimal interaction.

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Recently, a novel gene family encoding voltage-gated chloride channels, the ClC family, was identified. In some patients (two out of six) the appearance of lymphoblastoid B cells is cyclical.

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Mannose binding lectin (MBL) is a pattern recognition molecule that plays a pivotal role in innate immunity. DPP11 is a novel enzyme specific for acidic P1 residues (Asp and Glu) and distributed ubiquitously in eubacteria, while DPP5 is preferential for the hydrophobic P1 residue and the first entity identified in prokaryotes.

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Dose of Interferon was escalated gradually to a maximum dose of 3 MIU tiw according to clinical follow-up. The limbal area in horizontal cut direction showed that limbal epithelial cells were as papilloma-form to correspond to the Palisades of Vogt environment. It was demonstrated that stimulation with large doses of the antigen caused degranulation of peritoneal mast cells and that additional administration of a beta antagonist propranolol failed to increase the degranulation phenomenon. We explored the relationship between in vivo CB(1) receptor occupancy in the frontal cortex and changes in both monoamine release in the medial prefrontal cortex (mPFC) and feeding behavior in rats in response to two orally administered CB(1) receptor antagonists presently in clinical trials, SR141716A (rimonabant) and SLV319.

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To evaluate the contribution of cellular dysfunction and neuronal loss to brain N-acetylaspartate (NAA) depletion, NAA was measured in brain tissue by HPLC and UV detection in rats subjected to cerebral injury, associated or not with cell death. The majority of these lesions either require further investigation, treatment or they affected the prognosis of the patient. Cortical pathology was widespread and posteriorly accentuated but spared the hippocampal dentate gyrus.

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Long-term effects of combined divalent copper and tetracycline on the performance, microbial activity and community in a sequencing batch reactor. Changes in avian and plant communities of aspen woodlands over 12 years after livestock removal in the Northwestern Great Basin. Dietary factors play a role in the development of CVD and associated comorbid conditions, yet surprisingly few data exist to describe the dietary intakes and nutritional adequacy of American Indian adults at risk for CVD. However, it is also an opportunity for the bioeconomy society if new uses for these residual materials can be found. This study describes the mental health status of community-living frail elders in Michigan and identifies subgroups of individuals who are vulnerable to mental health problems.

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CASE REPORT We present here a case of a 64-year-old female patient with T9 and T10 acute osteoporotic fractures, treated previously with vertebroplasty for four levels of osteoporotic vertebral fractures. Steroidogenic assessment using ovary culture in cycling rats: effects of bis(2-diethylhexyl)phthalate on ovarian steroid production.

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Ruffini corpuscles detect tension, rapidly adapting lamellated corpuscles detect pressure and vibration in the periodontium. Physical activity appeared to have an indirect association with serum lipid and lipoprotein values through its relationship with higher fitness levels and lower levels of fatness. By contrast, when males or females mated repeatedly with the same mate, copula duration was repeatable.

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Tumefactive multiple sclerosis and hepatitis C virus 2a/2C infection: Dual benefit of long-term interferon beta-1a therapy? The results demonstrate the importance of dynamic patellar motion studies for diagnosis of patello-femoral maltracking. Tail proteins of phage T5: investigation of the effect of the His6-tag position, from expression to crystallisation. For all patients, efforts to reduce out-of-pocket costs and encourage use of mail order pharmacies may result in higher adherence. A sense of identity also appears to be important in change experiences.

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Research into the clinical management of amblyopia has, most recently, focussed on the effectiveness of amblyopia treatment. Systematic evaluation of exercise tolerance combined with a physical examination of the neurologic, visual, cervical, and vestibular systems can in many cases identify one or more treatable postconcussion disorders. Furthermore, XP-180 readily induced collapse of mitochondrial membrane potential after 2 h of incubation. In this study, we describe the viral kinetics of CVA16 in human rhabdomyosarcoma (RD) cells by analyzing the cytopathic effect (CPE), viral RNA replication, viral protein expression, viral RNA package and viral particle secretion in RD cells.