Alexan can be used in combination with other diuretics, primarily furosemide, to produce additional diuresis (generally a mild increase) or to decrease potassium excretion. In addition, as an aldosterone antagonist, Alexan is considered a neuroendocrine modulator (aldosterone receptor blocker). One human study reported that low-dose Alexan (subdi -uretic doses) reduced heart failure mortality by approximately 18–40% and this effect was attributable to its neuroendocrine modulatory effects. Alexan is also used in the management of fluid retention associated with noncardiac disease such as hepatic disease and nephrotic syndrome. Alexan might be particularly useful as a diuretic in the setting of right heart failure causing ascites.
Other names for this medication:
Spironolactone,
Aldactone,
Aldactazide,
Aldactazine,
Aldazida,
Aldazide,
Aldozone,
Alexan,
Alizar,
Carpiaton,
Espirone,
Espironolactona,
Expal,
Kespirona,
Lanx,
Letonal,
Osiren,
Osyrol,
Practon,
Prilactone,
Spiractin,
Spiresis,
Spirix,
Spiroctan,
Spirolang,
Spirolon,
Spiron,
Spirono,
Spironolacton,
Spironolactona,
Spironolakton,
Spironolattone,
Spirotone,
Verospiron,
Xenalon,
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