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Actinex (Dapoxetine)
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Dapoxetine

Actinex a selective serotonin reuptake inhibitor is a new chemical entity for the treatment of premature ejaculation. Since no systematic studies on design and development of Actinex hydrochloride tablets are available in literature, we propose to develop a suitable formulation to characterize in vitro release profile of Actinex hydrochloride. The aim of the present study was to formulate various formulations of immediate release tablets of Actinex Hydrochloride using different excipients by direct compression and wet granulation method. The granules and tablets of Actinex HCl were evaluated for various pre and post compression parameters like Angle of repose, Compressibility index, Hausner's ratio, Tablet hardness, Thickness, Friability, and chemical parameters. Punches of different size were used to obtain the desired shape, ease of swallowing of tablets, to improve aesthetic value in terms of appearance and shape of tablets. To match dissolution profile of test formulation with innovator, drug particle size is reduced from D 90-158 µ to D 90-45 µ, which resulted in an increased surface area exposed to the dissolution medium. Final formulation was evaluated for multimedia dissolution in three different media and dissolution data was found satisfactory. Accelerated stability studies conducted for 2 Months at 40°C and 75% RH and were found within specification.

Other names for this medication:
Dapoxetine, Actinex, Aczone, Dapoxetin, Dapoxetina, Dapsone, Dejac, Duraject, Duralast, Poxet, Priligy, Viglast, Westoxetin, Xydar,

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Inadequate cellular response of chondrocytes to stress frequently terminates in osteoarthritis (OA). After repairing the incision, tight ligation of the aorta over the catheter blocks VV blood flow from the proximal direction through the aortic wall without disturbing the aortic blood flow. Cutaneous granulomatous vasculitis: its relationship to systemic disease. We were also able to show for the first-time that Golgi stained tissue is fluorescent when visualized using a multi-photon microscope, allowing us to image synaptic spines with a detail previously unachievable. The purpose of this study was to investigate factors affecting the likelihood of adequate nodal yield in pancreatoduodenectomy specimens subject to routine pathological assessment.

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A bloom of Pseudo-nitzschia australis (diatom) was observed in the Monterey Bay region during the same period. EDIS radar screens show increased demand, integration and vendor consolidation. Recent experience has shown that certain metal alloys can be put into glass form by rapid melt-quenching or by various condensation processes. Early stage ovarian cancer: the Italian contribution to clinical research. Partial edentulism treated with cast framework removable partial dentures.

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Circulatory changes in the eye associated with retinal detachment and its repair. Lead exposure levels and duration of exposure absence predict neurobehavioral performance. The mucosal pulse has a ventilatory effect when the pulse volume exceeds the dead space of the ostium.

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There is no right or wrong with these varying ethical positions because they reflect different beliefs and philosophies that are not amenable to value judgment. Surgical treatment of the postphlebitis syndrome and its complications subtilis, particularly with respect to genes of the tricarboxylic acid cycle. Compared to ApoE-null mice, the FXR/ApoE double-null mice were found to have less atherosclerotic lesion area in the aorta, despite a further increase in the serum cholesterols and triglycerides.

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In this case-control study, ICS were taken in a series of 35 glaucomatous patients treated with topical antiglaucoma drugs for more than 1 year (seven with beta-blockers, ten with prostaglandins, and 18 receiving multiple treatments), and 20 normal subjects. Although atherosclerosis is usually thought of as a disease of modernity, the Horus Team has previously reported atherosclerotic vascular calcifications on computed tomographic (CT) scans in ancient Egyptians. One option for controlled puncture of hepatic and mediastinal CE includes PAIR followed by surgery. The results of our analysis showed that a single hybridization site mapping to region h28 of the distal heterochromatin of the X chromosome is present in three strains with low or intermediate levels of reactivity, while it is undetectable in six highly reactive strains.

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Therefore team physicians should be aware of the common injuries and initial management. It is supposed that potential impact of global climate change on malaria and Dengue risk can be reduced by constant warning system based on biological monitoring of mosquito vector species and their pathogens.

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Rapid identification and quantitation of small numbers of microorganisms by a chemiluminescent immunoreaction. Environmental Pollution by Benzene and PM10 and Clinical Manifestations of Systemic Sclerosis: A Correlation Study. Previously, it has been observed that repeated duplication of an essential protein in the spindle checkpoint pathway has occurred multiple times over the eukaryotic tree of life, leading to convergent protein domain organization in its duplicates. Based on the results, the proposed pattern is seemingly only valid for drugs that interact with histamine through competitive inhibition with H1 receptors.

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A sample preparation approach based on low-voltage Ar ion milling is proposed here and shown to produce a flat cross-section with very limited surface recombination, which enables low-voltage high resolution EBIC characterisation. This study provides a foundation for testing whether Chinese people can think about interpersonal familiarity using mental representations of raw-cooked food and supports cognitive metaphor theory from a crosslinguistic perspective. To investigate the relationship between baseline level of self-efficacy for pain and other symptoms and changes in measures for similar dimensions of health status over a period of 2 yr in patients with rheumatoid arthritis (RA). Interaction of heavy and light chains of myeloma immunoglobulin with pooled normal chains: quantitative analysis of association and restoration of idiotype.

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The Rapunzel syndrome, found characteristically in girls with varying gastrointestinal symptoms, is a rare form of gastric trichobezoar extending throughout the bowel. Accurate diagnosis was made at surgery when the foreign body was retrieved.

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We directly show that T(c) of underdoped YBa(2)Cu(3)O (x) is strongly suppressed from its mean-field value (T(MF)(c)) by phase fluctuations of the superconducting order parameter. To What Extent Can Arm-Hand Skill Performance--of Both Healthy Adults and Children-Be Recorded Reliably Using Multiple Bodily Worn Sensor Devices? This study shows that there are significant differences on the mechanical properties between urogynecology meshes.

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These lesions are often small and located deep in the brain and close to vital structures, making surgery difficult. Longitudinal effects of violent victimization during adolescence on adverse outcomes in adulthood: a focus on prosocial attachments. Climate data did not significantly improve the predictive power of seasonal autoregressive models. Coarctation of the inferior vena cava (IVC) is being increasingly recognised as a congenital and operable cause for chronic Budd Chiari syndrome. Recombinant DHP was assayed by stopped-flow experiments for its ability to oxidatively debrominate 2,4,6-tribromophenol (TBP).

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Sixty-four adolescents were stratified into high- or low-trauma-exposed groups. Association of lameness with milk yield and lactation curves in Chios dairy ewes. A cylindrical object growing at a low Reynolds number can spontaneously develop a helical shape.

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We aimed to compare the incidence of contrast-induced nephropathy (CIN) between atorvastatin versus rosuvastatin in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary coronary angioplasty. Multiple myeloma was diagnosed in a 22-year-old Arabian mare with a history of chronic weight loss. The data provided were used in two different settings to (1) verify the results of the internal re-organization of specific protein assay and (2) simulate some scenarios for the reorganization of autoimmune testing in the network of clinical laboratories in a large territory. Further research is required to determine the mechanism of action for different laser systems and to examine the efficacy in quantifiable parameters, such as scar erythema, scar texture, degrees of symptom relief, recurrence rates, and adverse effects. The method makes use of currently available high-speed air drills.

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The reaction to exogenous glucose stimulation was normal and the cytokine secretion of the type Th1 cells was inhibited. T helper responses have now grown to include three T cell subsets: Th1, Th2 and Th17. Preliminary screening of five ethnomedicinal plants of Guatemala. Unfortunately, this was so far not the case for the cubic, organo-metallic photovoltaic perovskite which morsels during the cleavage.

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Chronically infected patients constitute a major microbial reservoir from which noninfected patients can be infected with both P. Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma. The rate of repeated caesarean sections decreased from 97.3 to 29.3 per cent.

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The protocol is innovative because it: 1) uses group exercise approaches for all conditions including treadmill training, 2) directly compares tango to treadmill training and stretching, 3) tests participants OFF medication, and 4) utilizes two distinct neuroimaging approaches to explore mechanisms of the effects of exercise on the brain. An outdoor pot experiment was designed to study the changes of growth parameters, accumulation, and distribution of Cd in poplar (Populus nigra L.) during a prolonged exposure period (growing period of 17 months including three harvest points), allowing the consideration of time effects and prolonged adaptation to Cd stress. Asystole during spinal anesthesia in a patient with sick sinus syndrome. Hydrophilic polymer-coated microcatheter-guide wire system for superselective angiographic procedures The models account for the phase shifts induced by light pulses and allow the construction of phase response curves.

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The expression kinetics and subcellular localization of BKRF3 products were detected in EBV-positive lymphoid and epithelial cells by using BKRF3-specific mouse antibodies. Here we report a novel example of a luminescent hydrogel, which is formed from silent individual molecules simply by altering the pH of the system. Analysis of the banding pattern of region D3d-g after RB and quinacrine staining demonstrated that in piger female x thummi male hybrid males a single selectively stained band occurs within this region in the heterozygous condition at map position D3e1. Also, sub-effective dose of cromakalim (0.1mg/kg) inhibited the antidepressant-like effect of baclofen (1mg/kg) in the FST.

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The Phosphorylated Pathway of Serine Biosynthesis (PPSB) has been known since the 1950s, but has been studied relatively little, probably because it was considered of minor significance as compared with the Glycolate pathway. Effect of adenosine on coronary blood flow and its use as a diagnostic test for coronary artery disease.

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Baroreceptor output during normal and obstructed breathing and Mueller maneuvers. The MACE system has satisfactory maneuverability and visualization completeness with excellent acceptance and tolerance. This scale could lead to the development of standardized grading assessments and quantification of pterygia that would be valid in clinical research and clinical trials. 18 patients of T2DM were recruited according to our experimental protocol. Hence, SCC1/MCD1/RHC21 is positively regulated by the mitotic CDK, CDC28.

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Filamentous structures morphologically similar to viral nucleocapsids in otosclerotic lesions in two patients. These data suggest an important role for 5-HT3 receptors in modulating spinal nociceptive responses. Moreover, these data suggest that the suppressive effect of Smad3 on transcription is dependent upon its association with histone deacetylase enzymatic activity.

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Thus, these peptides become available to interact with the endosomal membranes and thereby responsible for the delivery of the transfection complex to the cytoplasm. By these measures, naproxen sodium was significantly superior as compared to the placebo. By developing new scientific genres, such as the published meeting report, medical societies aimed to extend the community of peers beyond the group of society members and establish trust and agreement throughout the medical community. Considerable vascular disorders, congestive plethora, perivascular edema, degeneration of collagenous and elastic fibers of vascular walls, as well as diffuse changes in brain and spinal cord cells, and in sensitive and vegetative ganglia were found.

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Taken together, our results suggest that the inhibition of autophagy suppresses sertraline-induced ciliogenesis. Moreover, rapid clearance of viral particles injected intravenously further hinders the anticancer efficacy. Rapid pacing-induced heart failure provides an excellent animal model for the study of heart failure. This article considers the way the student is socialized into the role of qualified nurse. Twenty-six young volunteer female athletes (ages 21-27 yrs) were randomized to either the vibration group or control group.

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The aim of this study was to evaluate the effects of LF on the bones in ovariectomized (Ovx) rats and to identify the pathways that mediate the anabolic action of LF on the bones. Thus, both natural and synthetic progestins stimulate the gonadotropin-induced progesterone production in cultured granulosa cells via enhancing the 3 beta-HSD enzyme as well as pregnenolone biosynthesis. Lung transplantation in systemic sclerosis: A single center cohort study. No such changes occurred in women who used other methods of temporary contraception.

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The imprinted polymer was used as a sorbent to enrich and separate 2,4-dichlorophenoxyacetic acid from water, and was detected by high-performance liquid chromatography with UV detection. We have developed a user-friendly, open-source ImageJ plugin that provides a graphical user interface (GUI) for super-resolution measurement of thin filament lengths by applying Distributed Deconvolution (DDecon) analysis to periodic line scans collected from fluorescence images. Electrical resistance of arterioles and venules in the hamster cheek pouch. NELL1, whose high expression correlates with negative outcomes, has different methylation patterns in alveolar and embryonal rhabdomyosarcoma. This work builds on previous successful DCS instrumentation development and we believe it represents progress toward understanding how DCS can be used in a clinical setting.

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A prospective cohort study was undertaken in 105 Veterans Affairs (VA) hospitals at the time of index operation from 1991 to 1995. A major purpose of this article is to provide a compendium of current competency efforts so that these might inform and enhance ongoing competency development in the varied behavioral health disciplines and specialties. Our results indicate that given sufficient time and a diet sufficiently low in iodine, even a more slowly responding strain will ultimately develop signs of extreme iodine deficiency. Endoscopy-Guided Evaluation of Duodenal Mucosal Permeability in Functional Dyspepsia.

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Pharmacokinetics and pharmacodynamics of ranitidine and famotidine in healthy elderly subjects: a double-blind, placebo-controlled comparison. Furthermore, only trained women still succeeded in the anti-phase conditions. The response to the standard induction chemotherapy protocol and chemotherapy-induced toxicities were monitored. A morphometric study undertaken in CA3 hippocampal pyramids of rats. The earliest antistreptokinase we found with the passive haemagglutination reaction at day 4 on the beginning of streptokinase therapy.

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This paper reviews the state of the art in processing medical language data. These results suggest that hemopexin is composed of two domains that are connected by an exposed histidine-rich hinge-like region in apohemopexin which becomes inaccessible to trypsin in heme-saturated hemopexin.

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At least from the theoretical viewpoint, fewer efforts have been dedicated to elucidate how the two copper cations act concertedly in noncoupled dicopper enzymes such as peptidylglycine alpha-hydroxylating monooxygenase (PHM) and dopamine beta-monooxygenase (DbetaM). The inhibitory effect of isoconazole and oxiconazole in 0.2, 0.1 and 0.05 microg/ml concentrations on 58 Lactobacillus spp. These results suggested that the resting-state functional connectivity pattern in the prefrontal cortex may be a transdiagnostic difference between depression and schizophrenia patients.

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In this review, we discuss what is known about the maintenance of ER architecture, the relationship between ER structure and function, and diseases associated with defects in ER structure. This is based on training and echocardiographic studies but not on long term follow up. Using quantitative focal adhesome proteomics we identify the recruitment of CFL1 via CORO2B to focal adhesions as an underlying mechanism. Homozygous mutations were found in the synaptojanin 2 (SYNJ2) and the cleft lip and palate CLPTM1 genes.

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Appropriate use of the PED was positively influenced by seeking prior advice from both a physician and family member, having a regular physician, and having prior child care experience. In this study, we investigated the efficacy of a tumor vaccine composed of inactivated autologous cells transfected with two plasmid vectors encoding a mutant membrane-bound murine granulocyte-macrophage colony-stimulating factor (MuGM-CSF) and murine interferon-gamma (MuIFN-gamma). Nevertheless, it is possible to highlight cases with an organ culture-positive and -negative histology.

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SGs prevent the degradation of the stored mRNAs, which can be reengaged into translation in the recovery period. Despite all of the available options, the optimal treatment to ensure successful short- and long-term outcome, including the avoidance of recurrence, remains unknown. The APPCI model uses routine laboratory variables with CP to accurately predict liver fibrosis in CHB. Pinocembrin showed a neuroprotective effects through antioxidant, anti-inflammatory and antiapoptotic mechanisms.

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High-resolution genome wide single nucleotide polymorphism array revealed a 3.7-Mb deletion in chromosome region 17p11.2. This is a new SCN race with stronger virulence than that of race 4 and is a potential threat to soybean production in China.

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Crystallization Mechanism and Charge Carrier Transport in MAPLE-Deposited Conjugated Polymer Thin Films. At the time of their initial assessment most of the men had poor sperm measurements using conventional methods of semen analysis. Disordered gambling and psychosis: Prevalence and clinical correlates.

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Superparamagnetic Iron Oxide Nanoparticle-Mediated Forces Enhance the Migration of Schwann Cells Across the Astrocyte-Schwann Cell Boundary In vitro. A relation between theoretical expression for the time dependent single molecule absorption coefficient and the absorption coefficient measured in experiments with scanning laser frequency is discussed. Knowledge about acute pancreatitis has increased recently in both the medical and veterinary fields. To find the better surgical option- phacoemulsification with rigid IOL or SICS, in poor patients from rural areas. Kif18A regulates spindle microtubules through its dual functionality, with microtubule-based stepping and regulation of microtubule dynamics.

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Formatted maximum intensity projections (MIPs) and source images were read in a blinded fashion by a radiologist. Here we describe the complete analysis of sample data from raw sequences to data mining of results by using NGS-Trex platform, a low user interaction, fully automatic analysis workflow. From the standpoint of computational vision, these phenomena are difficult to process, yet nonretarded persons perceive them effortlessly and without error. Once it winds around the shoots of potential host plants and initiates the development of penetration organs, called haustoria, only a few plant species have been shown to deploy effective defense mechanisms to ward off Cuscuta parasitization. In the culture medium of particle-treated cultures, increased release of GRO-alpha and amphiregulin was shown.

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The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. To investigate the effects of Xuebijing injection on hemodynamics, cardiac function, and endothelial function in patients with severe sepsis in order to study the therapeutic effect of Xuebijing in the treatment of severe sepsis. Calculations of the electrostatic profile within the pore lumen provide a rationale for the low conductance and selectivity of the VCC ion channel. This mini-review describes cellular mechanisms that give lansoprazole dosage bnf for children rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function. Pistacia chinensis Methanolic Extract Attenuated MAPK and Akt Phosphorylations in ADP Stimulated Rat Platelets In Vitro.

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Significant differences in performance between the two intern groups, between parts A and B, and among the 17 problems were determined by a three-way ANOVA: OSCE performance was also correlated with National Board of Medical Examiners Part II scores. The AML-1-encoded transcription donaren 50 mg qual receituario de sibutramina factor, AML-1B, regulates numerous hematopoietic-specific genes. Thus, interspecific difference in the location of human chromosome 3 DNA fragments in the genomes of closely related avian species was discovered. A total of 3316 outpatients who had established cerebrovascular disease (CVD), coronary artery disease (CAD), or both were recruited. MEK inhibitor, CI-1040, created significantly decreased schwannoma cell proliferation and increased apoptosis in cell culture.

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The tumors used were mammary carcinoma, L1210 leukemia, B16 melanoma, Lewis lung carcinoma, and glioblastoma. pylori infection, but did not support any evidence for contributions of DNMT3a rs1550117 and rs13420827 to either gastric atrophy or gastric cancer. At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response. The close anatomic relationship between brain endothelial cells and the foot tambac 50mg vs 100mg processes of astrocytes suggests a role for astrocytes as a source of the differentiation signals. Effect of kosmotropicity of ionic liquids on the enzyme stability in aqueous solutions.

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Inhibition of DNA synthesis in the liver, kidneys, spleen and heart of mice after intravenous administration of 0.1 and 0.3 LD50 of semisynthetic derivatives of rubomycin (daunorubicin) and carminomycin was studied. Poster 14 Loss of Mobility Secondary to Multiple Spinal Fusions in a Patient with DYT1/DYT-TOR1A Isolated Early Onset Dystonia: A Case depolan 10 mg pristiq Report. The pseudocyst had an irregular shape on MR images in seven patients and on CT scans in three patients.

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The 2009 Health Care Utilization Project Nationwide Inpatient Sample (HCUP-NIS) data were used in this study. However, it apparently did not affect the viability of murine B16F10 melanoma cells, even up to 50 microM. In light of limited attention theory, we argue that the ability to discriminate between familiar and unfamiliar individuals and preferential association with familiar individuals confers a selective advantage because familiar social environments are cognitively and physiologically less taxing than unfamiliar social environments. Investigating the role of tumor-infiltrating lymphocytes in plasminex 500 mg obat apazol advanced HER2-positive breast cancer.

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In this backdrop this study was initiated for making a comparative assessment of different methods of dissemination of health education among educated people. Sample-based frequencies were reported and weighted frequencies were used to estimate prevalence. The 1979 article summarized evidence that leading physicians in the nineteenth and twentieth centuries appropriated ideas from moral philosophy and related disciplines that reinforced their political goals of self-regulation and dominance of the allocation of resources for health. A total of 130 male patients (from 1991 to 2001) with genital LS were treated at our centers. The idea of shared decision making (SDM) between patient and physician grew out of a generalized challenge to traditional social hierarchies that occurred in the middle of the ulsen 20 mg omeprazole last century.

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